ArticleThe journal of nutrition, health & aging2021
Vitamin B12 and Folate Status in Cognitively Healthy Older Adults and Associations with Cognitive Performance.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review.Frontiers in aging neuroscience · 2025Pooled it
- Association Between Methylmalonic Acid and Cognition: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Vitamin B12, Homocysteine and Cognitive Impairment in Elderly Patients with Type 2 Diabetes.Journal of clinical medicine · 2026Article
- One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.Biochemistry and biophysics reports · 2026Review
- Advances in Nanoparticle-Based Vitamin Delivery Systems for Precision Nutrition and Improved Bioavailability.AAPS PharmSciTech · 2026Review
- Rapid Restoration of Circulating Vitamin B12 Levels by Using Oral SucrosomialPharmaceutics · 2026Article
- Association of MTHFR C677T and A1298C Polymorphisms in Metabolic Alterations, Neuroimaging, and Cognitive Decline in Alzheimer's Disease: Case-Control and Bioinformatics Insights.Molecular neurobiology · 2025Article
- Glycated hemoglobin levels and geriatric depression impact cognitive status in an Indian urban elderly community.IBRO neuroscience reports · 2025Article
- Higher vitamin BAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Unlocking the Potential of Red Seaweeds: A Special Focus onMarine drugs · 2025Review
- Food insecurity and cognitive domains among older United States adults: Findings from the health and retirement study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Comparison of Nutrient Intake Across Different Dietary Patterns in Brazilian Community-Dwelling Older Adults.Nutrients · 2025Article
- Association analysis between circulating methylmalonic acid and cognitive performance: a population-based cross-sectional study.Frontiers in neurology · 2025Article
- Associations between folate metabolism biomarkers and cognitive impairment in older Chinese adults: a cross-sectional study.Frontiers in medicine · 2025Article
- Optical bio/chemical sensors for vitamin BBeilstein journal of nanotechnology · 2025Review
- Review
- Hyperhomocysteinemia and its effect on ageing and language functions - HEAL study.Scientific reports · 2024Article
- Comparative bioavailability study of supplemental oral SucrosomialFrontiers in nutrition · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine prevalence of vitamin B12 and folate deficiency and associations with cognitive performance in participants recruited for the Cognitive Health in Ageing Register: Investigational, Observational, and Trial Studies in Dementia Research: Prospective Readiness cOhort Study (CHARIOTPRO) SubStudy (CPRO-SS).
designCross-sectional analysis of data collected in the screening phase for the CPRO-SS.
settingParticipants were recruited from the Chariot Register at Imperial College London comprising approximately 39,000 community dwelling volunteers.
participantsCommunity dwelling individuals aged 60-85 years with B vitamin biomarker measures available were included (n=1946). After medical history and other exclusions, 1347 cognitively healthy participants were included for analysis of cognitive data. MEASUREMENTS: Cognitive status was assessed with the Repeatable Battery for Neuropsychological Status (RBANS). Assays included vitamin B12 and folate, followed by serum methylmalonic acid and homocysteine levels for those with low vitamin B12. Gender-specific linear regression analysis was performed for associations between cognition and biomarkers. Non-gender specific regression for groups graded by B vitamin deficiency severity were also performed.
resultsVitamin B12 deficiency (<148pmol/L) was found in 17.2% of individuals and folate deficiency (<10nmol/L) in 1% of our participants. Low vitamin B12 was associated with poorer memory (p<0.03) in men. A high BMI predicted poorer attention and visuospatial indices (p<0.05). A regression analysis by B12 level revealed associations with poorer attention (β -6.46; p=0.004) for the deficient group and with immediate memory (β -2.99; p=0.019) for those categorised as severely deficient.
conclusionOlder men and women are prone to vitamin B12 deficiency with associated subtle and different domain-specific disruptive effects in measures of memory and attention. Elevated homocysteine and methylmalonic acid contributed to poorer cognitive performance. Novel groups at particular risk of cognitive deficit were identified for future interventional studies in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.