Evidence map›Paper›PMID 33575659›Full record

ArticleRadiology. Imaging cancer2021

Assessing Oximetry Response to Chimeric Antigen Receptor T-cell Therapy against Glioma with

Fanny Chapelin, Benjamin I Leach, Ruifeng Chen, Deanne Lister, Karen Messer, Hideho Okada, Eric T Ahrens

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  8. Oxygen-Carrying Capacity of Perfluorohexyloctane, a Novel Eye Drop for Dry Eye Disease.Current therapeutic research, clinical and experimental · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fanny ChapelinDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).ORCID 0000-0001-9340-743X
Benjamin I LeachDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).
Ruifeng ChenDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).ORCID 0000-0003-4892-9233
Deanne ListerDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).
Karen MesserDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).
Hideho OkadaDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).
Eric T AhrensDepartment of Biomedical Engineering, University of Kentucky, Lexington, Ky (F.C.); Department of Radiology (B.I.L., D.L., E.T.A.), Department of Biostatistics and Bioinformatics (R.C.), and Department of Family Medicine and Public Health (K.M.), University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093; Department of Neurologic Surgery, University of California San Francisco, San Francisco, Calif (H.O.); and Parker Institute for Cancer Immunotherapy, San Francisco, Calif (H.O.).ORCID 0000-0001-6131-9304
University of California San Diego · US

Funding

CLINICAL TRANSLATION OF 19F MRI TO VISUALIZE CANCER IMMUNOTHERAPEUTIC CELLSR01CA134633 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T., COHEN, EZRA · 2009 to 2021
$4.4M
Compositions and methods for enhanced fluorine-19 magnetic resonance imaging cell trackingR01EB024015 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T. · 2017 to 2020
$2.3M
Intracellular oxygen sensing using 19F MRIR01EB017271 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T. · 2013 to 2016
$1.3M
NCI NIH HHS R01 CA134633NIBIB NIH HHS R01 EB017271NIBIB NIH HHS R01 EB024015
6 · The paper itself

Abstract

Purpose: To assess the cell-specific, intracellular partial pressure of oxygen (Po Materials and Methods: Human glioblastoma cells or human T cells were intracellularly labeled with perfluorocarbon nanoemulsion droplet sensors prior to in vivo injection in severe combined immunodeficient mice to measure Po Results: The intracellular tumor cell Po Conclusion: Cell-specific Po

Indexed as

GliomaReceptors, Chimeric AntigenAnimalsCell- and Tissue-Based TherapyDisease Models, AnimalMagnetic Resonance ImagingMiceMice, SCIDOximetryReceptors, Chimeric Antigen

Identifiers

PMID33575659
PMCPMC7850236
OpenAlexW3124413055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.