Evidence map›Paper›PMID 33575658›Full record

ArticleRadiology. Imaging cancer2021

Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of Hepatocellular Carcinoma.

Wooram Park, Soojeong Cho, Jingran Ji, Robert J Lewandowski, Andrew C Larson, Dong-Hyun Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Sorafenib-Drug Delivery Strategies in Primary Liver Cancer.Journal of functional biomaterials · 2025
    Review
  3. Application of Nanotechnology in TACE Treatment of Liver Cancer.International journal of nanomedicine · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wooram ParkDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.ORCID 0000-0002-4614-0530
Soojeong ChoDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.
Jingran JiDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.
Robert J LewandowskiDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.
Andrew C LarsonDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.ORCID 0000-0002-1223-7406
Dong-Hyun KimDepartment of Radiology, Feinberg School of Medicine (W.P., S.C., J.J., R.J.L., A.C.L., D.H.K.), and Robert H. Lurie Comprehensive Cancer Center (R.J.L., A.C.L., D.H.K.), Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611; Department of Biomedical Engineering (A.C.L., D.H.K.); and Department of Electrical Engineering and Computer Science (A.C.L.) and International Institute of Nanotechnology (A.C.L.), Northwestern University, Evanston, Ill.ORCID 0000-0001-6815-3319
Northwestern University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern University

Funding

MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver TumorsR01CA181658 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LARSON, ANDREW CHRISTIAN · 2015 to 2019
$2.1M
Catheter-Directed Image-Guided Delivery of Cytostatic and Cytotoxic Combination Therapy to Liver TumorsR01CA218659 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DONG-HYUN · 2018 to 2022
$1.9M
Image-Guided Transcatheter Delivery of Natural Killer Cell Therapy Augmented with IFN-Gamma Eluting MicrospheresR01EB026207 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DONG-HYUN · 2018 to 2021
$1.4M
NCI NIH HHS R01 CA181658NCI NIH HHS R01 CA218659NIBIB NIH HHS R01 EB026207
6 · The paper itself

Abstract

Purpose: To validate the therapeutic efficacy of sorafenib-eluting embolic microspheres (SOR-EMs) used in combination with transarterial chemoembolization (TACE) for treatment of hepatocellular carcinoma (HCC) in a preclinical animal model. Materials and Methods: SOR-EMs were prepared with poly(d,l-lactide- Results: The SOR-EMs were a mean size of 6.6 μm ± 2.3 (standard deviation) and showed 53.7% ± 8.3 sorafenib loading efficiency with T2-weighted MRI capability. In the HCC rat model, the intra-arterially injected SOR-EMs were successfully monitored by using MRI. The DLE + SOR-EM-treated rats showed a superior tumor growth-inhibitory effect compared with the rats treated with DLE only ( Conclusion: In a preclinical rat HCC model, SOR-EMs used in combination with DLE TACE were effective in treating HCC.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsAnimalsMicrospheresRatsSorafenibSorafenib

Identifiers

PMID33575658
PMCPMC7850235
OpenAlexW3120596325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.