Evidence map›Paper›PMID 33575630›Full record

ArticleNAR genomics and bioinformatics2020

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits.

Gerard A Bouland, Joline W J Beulens, Joey Nap, Arno R van der Slik, Arnaud Zaldumbide, Leen M 't Hart, Roderick C Slieker

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gerard A BoulandDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Joline W J BeulensDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, 1081 HV, Amsterdam, The Netherlands.
Joey NapDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Arno R van der SlikDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Arnaud ZaldumbideDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Leen M 't HartDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Roderick C SliekerDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.ORCID 0000-0003-0961-9152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous large genome-wide association studies have been performed to understand the influence of genetics on traits. Many identified risk loci are in non-coding and intergenic regions, which complicates understanding how genes and their downstream pathways are influenced. An integrative data approach is required to understand the mechanism and consequences of identified risk loci. Here, we developed the R-package CONQUER. Data for SNPs of interest are acquired from static- and dynamic repositories (build GRCh38/hg38), including GTExPortal, Epigenomics Project, 4D genome database and genome browsers. All visualizations are fully interactive so that the user can immediately access the underlying data. CONQUER is a user-friendly tool to perform an integrative approach on multiple SNPs where risk loci are not seen as individual risk factors but rather as a network of risk factors.

Identifiers

PMID33575630
PMCPMC7671384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.