Evidence map›Paper›PMID 33575620›Full record

ArticleNAR genomics and bioinformatics2020

An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects.

Zhenxing Guo, Ying Cui, Xiaowen Shi, James A Birchler, Igor Albizua, Stephanie L Sherman, Zhaohui S Qin, Tieming Ji

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenxing GuoDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.
Ying CuiDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.
Xiaowen ShiDivision of Biological Sciences, University of Missouri at Columbia, Columbia, MO 65211, USA.
James A BirchlerDivision of Biological Sciences, University of Missouri at Columbia, Columbia, MO 65211, USA.
Igor AlbizuaDepartment of Human Genetics, Emory University, Atlanta, GA 30322, USA.
Stephanie L ShermanDepartment of Human Genetics, Emory University, Atlanta, GA 30322, USA.
Zhaohui S QinDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.
Tieming JiDepartment of Statistics, University of Missouri at Columbia, Columbia, MO 65211, USA.ORCID 0000-0002-1915-5892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We are motivated by biological studies intended to understand global gene expression fold change. Biologists have generally adopted a fixed cutoff to determine the significance of fold changes in gene expression studies (e.g. by using an observed fold change equal to two as a fixed threshold). Scientists can also use a

Identifiers

PMID33575620
PMCPMC7671412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.