Evidence map›Paper›PMID 33575525›Full record

ArticlePeptide science (Hoboken, N.J.)2020

Bent Into Shape: Folded Peptides to Mimic Protein Structure and Modulate Protein Function.

Haley I Merritt, Nicholas Sawyer, Paramjit S Arora

Open access · greenAbstract read
In one paragraph

Article in Peptide science (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 64 citations in OpenAlex.

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  13. Macrocyclic β-Sheets Stabilized by Hydrogen Bond Surrogates.Angewandte Chemie (International ed. in English) · 2023
    Article
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  18. Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Haley I MerrittDepartment of Chemistry New York University, New York, New York 10003, United States.
Nicholas SawyerDepartment of Chemistry New York University, New York, New York 10003, United States.
Paramjit S AroraDepartment of Chemistry New York University, New York, New York 10003, United States.
New York University · US

Funding

Protein Domain Mimics as Modulators of Biomolecular InteractionsR35GM130333 · NIGMS · NEW YORK UNIVERSITY · PI Paramjit S Arora · 2019 to 2026
$6.0M
Inducing Native-like Folding of Intrinsically Disordered Proteins using Stabilized a-Helical PeptidesF32GM120853 · NIGMS · NEW YORK UNIVERSITY · PI SAWYER, NICHOLAS ALAN · 2016 to 2018
$171k
NIGMS NIH HHS F32 GM120853NIGMS NIH HHS R35 GM130333
6 · The paper itself

Abstract

Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here we review contemporary methods to reproduce loop, helix, sheet and coiled-coil conformations in short peptides.

Identifiers

PMID33575525
PMCPMC7875438
OpenAlexW2997811773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.