Evidence map›Paper›PMID 33575418›Full record

ArticleOpen forum infectious diseases2021

Validation of N95 Filtering Facepiece Respirator Decontamination Methods Available at a Large University Hospital.

Krista R Wigginton, Peter J Arts, Herek L Clack, William J Fitzsimmons, Mirko Gamba, Katherine R Harrison, William LeBar, Adam S Lauring, Lucinda Li, William W Roberts and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. The COVID-19 pandemic and N95 masks: reusability and decontamination methods.Antimicrobial resistance and infection control · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Mask disinfection using atmospheric pressure cold plasma.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hydrogen Peroxide Methods for Decontaminating N95 Filtering Facepiece Respirators.Applied biosafety : journal of the American Biological Safety Association · 2021
    Review
  15. Assessment of saliva interference with UV-based disinfection technologies.Journal of photochemistry and photobiology. B, Biology · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Krista R WiggintonDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Peter J ArtsDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Herek L ClackDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
William J FitzsimmonsDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
Mirko GambaDepartment of Aerospace Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Katherine R HarrisonDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
William LeBarDepartment of Pathology, Clinical Microbiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Adam S LauringDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.ORCID 0000-0003-2906-8335
Lucinda LiDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
William W RobertsDepartment of Urology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Nicole C RockeyDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Jania TorreblancaDepartment of Pathology, Clinical Microbiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Carol YoungDepartment of Pathology, Clinical Microbiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Loïc G AndereggDepartment of Physics, Harvard University, Cambridge, Massachusetts, USA.
Amy M CohnDepartment of Industrial & Operations Engineering, University of Michigan, Ann Arbor, Michigan, USA.
John M DoyleDepartment of Physics, Harvard University, Cambridge, Massachusetts, USA.
Cole M MeisenhelderDepartment of Physics, Harvard University, Cambridge, Massachusetts, USA.
Lutgarde RaskinDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Nancy G LoveDepartment of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Keith S KayeDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
University of Michigan · USHarvard University · USMichigan Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to unprecedented shortages in N95 filtering facepiece respirators, healthcare systems have explored N95 reprocessing. No single, full-scale reprocessing publication has reported an evaluation including multiple viruses, bacteria, and fungi along with respirator filtration and fit.

methodsWe explored reprocessing methods using new 3M 1860 N95 respirators, including moist (50%-75% relative humidity [RH]) heat (80-82°C for 30 minutes), ethylene oxide (EtO), pulsed xenon UV-C (UV-PX), hydrogen peroxide gas plasma (HPGP), and hydrogen peroxide vapor (HPV). Respirator samples were analyzed using 4 viruses (MS2, phi6, influenza A virus [IAV], murine hepatitis virus [MHV)]), 3 bacteria (

resultsHeat with moderate RH most effectively inactivated virus, resulting in reductions of >6.6-log

conclusionsBoth moist heat and HPV are scalable N95 reprocessing options because they achieve high levels of biological indicator inactivation while maintaining respirator fit and integrity.

Indexed as

decontaminationinactivationN95reprocessingvirus

Identifiers

PMID33575418
PMCPMC7863868
OpenAlexW3111248749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.