SynthesisBioMed research international2021
Association between Frailty and Mortality, Falls, and Hospitalization among Patients with Hypertension: A Systematic Review and Meta-Analysis.
Synthesis in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Frailty and Mortality, Falls and Hospitalisation Among Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Hypertension Treatment in Frail Older Adults: A Systematic Review and Appraisal of Guidelines.Drugs & aging · 2023Pooled it
- The Effects of 12-Week Dual-Task Physical-Cognitive Training on Gait, Balance, Lower Extremity Muscle Strength, and Cognition in Older Adult Women: A Randomized Study.International journal of environmental research and public health · 2023Trial
- Frailty in rheumatoid arthritis and the general population: a cross-sectional analysis of the Groningen Frailty Indicator and Fried criteria.Rheumatology (Oxford, England) · 2026Article
- Prediction Models for Frailty in People Living With HIV: Protocol for a Systematic Review and Meta-Analysis of Prognostic Models.JMIR research protocols · 2026Article
- Association of Clinic Blood Pressure and Out-of-Clinic Blood Pressure Difference With Falls Among Older Adults With Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- The effectiveness of motivational interviewing on self-management in older adults with hypertension and frailty: study protocol for a randomized controlled trial.Frontiers in public health · 2026Article
- The relationship between cognitive function and quality of life in older hypertension patients: a parallel mediation effect of frailty and medication discrepancies.BMC geriatrics · 2025Article
- Article
- Frailty, All-Cause Mortality, and Hospitalization in Patients on Maintenance Hemodialysis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Association of changes in frailty with mortality in the aged with hypertension.Scientific reports · 2025Article
- Falls, Sleep Disorders and Cognitive Frailty in Hospitalized Older Adults with Hypertension:A Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Nationwide assessment of fall risk and protective factors among older adults in Saudi Arabia.PloS one · 2025Article
- The lived experience of frailty: beyond classification and towards a holistic understanding of health.European geriatric medicine · 2024Article
- Review
- Associations among frailty status, hypertension, and fall risk in community-dwelling older adults.International journal of nursing sciences · 2024Article
- Correlates of Frailty in Hospitalized Older Adults with Hypertension and Its Influence on Clinical Prognosis.International journal of general medicine · 2024Article
- The Role of Sirtuins in Sarcopenia and Frailty.Aging and disease · 2023Article
- The Role of Cognitive Performance and Physical Functions in the Association between Age and Gait Speed: A Mediation Study.Geriatrics (Basel, Switzerland) · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChronological age alone does not adequately reflect the difference in health status of a patient with hypertension. Frailty is closely associated with biological age, and its assessment is clinically useful in addressing the heterogeneity of health status. The purpose of our study is to comprehensively examine the predictive value of frailty for negative health outcomes in hypertensive patients through a systematic review and meta-analysis.
methodsMultiple English and Chinese databases were searched from inception to 04.11.2020. All cross-sectional and longitudinal studies that examined the association between frailty and relevant clinical outcomes among hypertensive patients were included. The NOS was used to assess the risk of bias of studies included in the analysis. Hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were pooled for outcomes associated with frailty.
resultsSix longitudinal studies and one cross-sectional study involving 17403 patients with hypertension were included in the meta-analysis. The risk of bias of all included studies was rated as low or moderate. The pooled HR of frailty related to mortality was 2.45 (95% CI: 2.08-2.88). The pooled HR of prefrailty and frailty-related injurious falls was 1.07 (95% CI: 0.83-1.37) and 1.89 (95% CI: 1.56-2.27), respectively. The pooled HR of prefrailty and frailty-related hospitalization was 1.54 (95% CI: 1.38-1.71) and 1.94 (95% CI: 1.17-3.24), respectively.
conclusionsThis systematic review suggests that frailty was a strong predictor of mortality, hospitalization, and injurious falls among patients with hypertension. Our findings indicate that assessment of frailty in patients with hypertension to guide their management may be necessary in clinical setting. However, our finding was based on very limited amount studies; thus, future studies are required to further validate the role of frailty in prediction of negative health outcomes in hypertensive patients as well as pay more attention to the following knowledge gaps: (1) the association between frailty and hypertension-related outcomes, (2) the significance of the association between different frailty models and relevant clinical outcomes, and (3) the predictive value of prefrailty for the negative health outcomes in people with hypertension.
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