ReviewHepatobiliary surgery and nutrition2021
Biliary complications after liver transplantation: current perspectives and future strategies.
Review in Hepatobiliary surgery and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06658665 (Nomogram for Predicting Postoperative Early Biliary Complication in Adult Patients Following Liver Transplantation), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nomogram for Predicting Postoperative Early Biliary Complication in Adult Patients Following Liver Transplantation: a Retrospective Study
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine Perfusion Ameliorates Nonanastomotic Strictures After Liver Transplantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Clinical and translational gastroenterology · 2026Pooled it
- Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.Hepatology international · 2024Guideline
- The safety and efficacy of the percutaneous balloon-expandable biodegradable magnesium biliary stents in patients with liver transplant.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Endoscopic management of bile leaks following T-tube removal in liver transplant recipients with end-to-end anastomosis using fully covered self-expandable metal stents.Journal of surgical case reports · 2026Article
- Predicting biliary complications after liver transplantation: a machine learning and nomogram-based exploratory study.BMC gastroenterology · 2026Article
- Review
- Retrospective Analysis of Risk Factors and Surgical Outcomes in Liver Transplant Recipients.Annals of transplantation · 2026Article
- Endoscopic treatment of biliary strictures after liver transplantation: balloon dilatation with stenting improves long-term outcomes.Updates in surgery · 2026Article
- Biliary complications following donation after brainstem death liver transplantation.World journal of gastrointestinal surgery · 2026Article
- All About Multiparametric MRI Evaluation in Biliary Tree Complications After Liver Transplant.Diagnostics (Basel, Switzerland) · 2025Article
- Short-term external biliary drainage in living donor liver transplantation using duct-to-duct anastomosis: a single-center experience.Annals of surgical treatment and research · 2025Article
- L-FABP as a Potential Biomolecular Marker of Liver Graft Injury.Journal of clinical medicine · 2025Article
- Combined endoscopic-percutaneous approach for magnetic compression anastomosis in post-transplant anastomotic biliary strictures.European radiology · 2025Article
- Managements of bile leakage after liver transplantation: Commentary on recent findings.World journal of gastrointestinal surgery · 2025Article
- The trans T-tube cholangial drainage versus percutaneous transhepatic cholangial drainage for the treatment of bile leakage at the biliary-enteric anastomosis: a retrospective study.Surgical endoscopy · 2025Article
- Review
- A biomimetic nanomedicine alleviates liver transplant-related biliary injury by sequentially inhibiting oxidative stress and regulating macrophage polarization via Nrf-2/HO-1 and JNK pathways.Materials today. Bio · 2025Article
- Stent placement can achieve same prognosis as endoscopic nasobiliary drainage in treatment of bile leakage after liver transplantation.World journal of gastrointestinal surgery · 2025Article
- Percutaneous transhepatic biliary drainage in patients with cholestasis following liver transplantation.Abdominal radiology (New York) · 2025Article
- Post-living donor liver transplant biliary strictures: prevalence, predictors, and long-term outcomes in a retrospective study.Clinical transplantation and research · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceLiver transplantation (LT) is a life-saving therapy for patients with end-stage liver disease and with acute liver failure, and it is associated with excellent outcomes and survival rates at 1 and 5 years. The incidence of biliary complications (BCs) after LT is reported to range from 5% to 20%, most of them occurring in the first three months, although they can occur also several years after transplantation.
objectiveThe aim of this review is to summarize the available evidences on pathophysiology, risk factors, diagnosis and therapeutic management of BCs after LT. EVIDENCE REVIEW: a literature review was performed of papers on this topic focusing on risk factors, classifications, diagnosis and treatment.
findingsPrincipal risk factors include surgical techniques and donor's characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non- anastomotic biliary strictures. MRCP is the gold standard both for intra- and extrahepatic BCs, while invasive cholangiography should be restricted for therapeutic uses or when MRCP is equivocal. About treatment, endoscopic techniques are the first line of treatment with success rates of 70-100%. The combined success rate of ERCP and PTBD overcome 90% of cases. Biliary leaks often resolve spontaneously, or with the positioning of a stent in ERCP for major bile leaks. CONCLUSIONS AND RELEVANCE: BCs influence morbidity and mortality after LT, therefore further evidences are needed to identify novel possible risk factors, to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques.
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