ArticleHepatobiliary surgery and nutrition2021
Severity of early allograft dysfunction following donation after circulatory death liver transplantation: a multicentre study.
Article in Hepatobiliary surgery and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- A Brief Model Evaluated Outcomes After Liver Transplantation Based on the Matching of Donor Graft and Recipient.Clinical and translational gastroenterology · 2025Article
- Dynamic immune cell profiling identified natural killer cell shift as the key event in early allograft dysfunction after liver transplantation.Cell proliferation · 2024Article
- Role of the portal system in liver regeneration: From molecular mechanisms to clinical management.Liver research (Beijing, China) · 2024Review
- Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation: Multicenter Propensity Score-matched Study.Journal of clinical and translational hepatology · 2023Article
- Tenofovir over Entecavir on Hepatocellular Carcinoma Prevention: Potential Mechanisms and Suitable Population.Liver cancer · 2023Article
- Highlights of constructing liver-relevantHepatobiliary surgery and nutrition · 2022Article
- Decreasing Significance of Early Allograft Dysfunction with Rising Use of Nonconventional Donors.Medicina (Kaunas, Lithuania) · 2022Article
- Developing a new nomogram to predict early allograft dysfunction after liver transplantation: a nudge in the right direction.Hepatobiliary surgery and nutrition · 2022Article
- Comment on: "Hepatobiliary surgery and nutrition · 2022Article
- Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation.Frontiers in surgery · 2022Article
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Authors and funding
18 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly allograft dysfunction (EAD) is associated with decreased graft and patient survival rates. This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death (DCD) liver transplantation (LT). Furthermore, the influence of operative time on EAD incidence was also evaluated.
methodsIn this retrospective, multicentre cohort study, nomograms were established based on a single-centre training cohort (n=321) and validated in a 3-center validation cohort (n=501).
resultsThe incidence rate of EAD was 46.4% (149/321) in the training cohort and 40.5% (203/501) in the validation cohort. Of the 149 EAD patients in the training cohort, 77 patients with either elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) were classified as having EAD type A, and the rest of the EAD patients were classified as having EAD type B. Recipients with EAD type B had lower graft and patient survival rates than recipients with EAD type A (P=0.043 and 0.044, respectively). We further developed a nomogram to predict EAD (graft weight, cold ischemia time, donor age, model for end-stage liver disease (MELD) score) and another nomogram to predict EAD type B (graft weight, cold ischemia time, MELD score). The nomograms for the prediction of EAD and EAD type B had good discrimination [concordance index (C-index) =0.712 (0.666-0.758), 0.707 (0.641-0.773)] and calibration [Hosmer-Lemeshow (HL) P=0.384, P=0.425] in the validation cohort. An increased operative time (>6 h) was associated with increased EAD and EAD type B incidence in the high-risk group (P=0.005, P=0.020, respectively).
conclusionsEAD type B was associated with decreased graft and patient survival rates. The novel nomograms effectively predicted the incidence of EAD and EAD type B in DCD LT patients.
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