ArticleFrontiers in surgery2020
Case Report: Surgical Closure of Chronic Soft Tissue Defects Using Extracellular Matrix Graft Augmented Tissue Flaps.
Article in Frontiers in surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Safety of Ovine Forestomach Matrix Across 474 Soft Tissue Defects: Interim Results from the Prospective Multicenter MASTRR Registry.Advances in therapy · 2026Article
- Functional soft tissue regeneration involving extremity tendons using ovine forestomach matrix grafts.Journal of surgical case reports · 2026Article
- Article
- Utilization of a Multi-Tissue Extracellular Matrix in Complex Wound Care in Gaza: A Case Series.Antibiotics (Basel, Switzerland) · 2025Article
- Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Article
- Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair.Journal of biomaterials applications · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic soft tissue defects are notoriously difficult to heal. Surgical reconstruction of chronic defects using tissue flaps is a routine approach for closure of challenging chronic defects. Due to the poor tissue quality of chronic defects and associated inflammation, infection and impaired blood supply the success of flap closure is marred by reported complication rates of 25-58%. Extracellular matrix (ECM)-based graft materials are commonly used for resolving chronic wounds and in plastic and reconstructive procedures to create a scaffold for tissue regeneration. We hypothesized combination use of ECM grafts with tissue flaps in a single-stage surgical procedure would reduce complications and improve outcomes in the closure of chronic soft tissue defects. We report a case series (
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