ReviewFrontiers in bioengineering and biotechnology2021
Opportunities and Challenges for Microbial Synthesis of Fatty Acid-Derived Chemicals (FACs).
Review in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reverse beta-oxidation for biochemical production: insights into the functional properties of key enzymes.BMB reports · 2026Review
- Recent trends in microbial production of alkanes.World journal of microbiology & biotechnology · 2025Review
- Tolerance to a Diet of ToxicToxins · 2025Article
- Identification of crucial roles of transcription factor IhfA on high production of free fatty acids inSynthetic and systems biotechnology · 2024Article
- Tuning Fatty Acid Profile and Yield inBioengineering (Basel, Switzerland) · 2023Article
- Ketosynthase mutants enable short-chain fatty acid biosynthesis in E. coli.Metabolic engineering · 2023Article
- Microbes of traditional fermentation processes as synthetic biology chassis to tackle future food challenges.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
6 authors.
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Abstract
Global warming and uneven distribution of fossil fuels worldwide concerns have spurred the development of alternative, renewable, sustainable, and environmentally friendly resources. From an engineering perspective, biosynthesis of fatty acid-derived chemicals (FACs) is an attractive and promising solution to produce chemicals from abundant renewable feedstocks and carbon dioxide in microbial chassis. However, several factors limit the viability of this process. This review first summarizes the types of FACs and their widely applications. Next, we take a deep look into the microbial platform to produce FACs, give an outlook for the platform development. Then we discuss the bottlenecks in metabolic pathways and supply possible solutions correspondingly. Finally, we highlight the most recent advances in the fast-growing model-based strain design for FACs biosynthesis.
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Registered trials
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