ArticleJournal of medical signals and sensors
The Relation between Atherosclerosis Plaque Composition and Plaque Rupture.
Article in Journal of medical signals and sensors. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Surface cues shape procoagulant properties of amyloidogenic microclots.Cell death & disease · 2026Review
- Spatial localization of arachidonic acid in human carotid atherosclerotic plaques reveals a pro-inflammatory metabolic program in macrophages.Frontiers in molecular biosciences · 2026Article
- Exercise Alleviates Atherosclerosis Through the Modulation of the NLRP3 Inflammasome.Current molecular medicine · 2026Review
- An Open Multifunctional FPGA-Based Pulser/Receiver System for Intravascular Ultrasound (IVUS) Imaging and Therapy.Sensors (Basel, Switzerland) · 2025Article
- Tianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis.In vitro cellular & developmental biology. Animal · 2025Article
- Article
- Diagnosis and Management of Acute Coronary Syndrome Patients Without Obstructive Epicardial Stenosis.Current cardiology reports · 2025Review
- Nutritional Advantages of Walnut (Food science & nutrition · 2025Review
- m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization.Frontiers in immunology · 2025Review
- Comparison of Filtering Methods for Calculating ARFI log(VoA) to Delineate Carotid Plaque Features, In Vivo.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025Article
- Associations between Various Inflammatory Markers and Carotid Findings in a Voluntary Asymptomatic Population Sample.International journal of molecular sciences · 2024Article
- Oral Nanoformulations in Cardiovascular Medicine: Advances in Atherosclerosis Treatment.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Photodynamic Therapy for Atherosclerosis.International journal of molecular sciences · 2024Review
- Nonalcoholic Fatty Liver Disease as a Potential Risk Factor for Cardiovascular Disease in Patients with Type 2 Diabetes: A Prospective Cohort Study.International journal of endocrinology · 2024Article
- Article
- Review
- Characterizing atherosclerotic tissues:Frontiers in bioengineering and biotechnology · 2023Article
- Ferroptosis: A potential target of macrophages in plaque vulnerability.Open life sciences · 2023Review
- Association between Arousals during Sleep and Subclinical Coronary Atherosclerosis in Patients with Obstructive Sleep Apnea.Brain sciences · 2022Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntima, media, and adventitia are three layers of arteries. They have different structures and different mechanical properties. Damage to intima layer of arteries leads to an inflammatory response, which is usually the reason for atherosclerosis plaque formation. Atherosclerosis plaques mainly consist of smooth muscle cells and calcium. However, plaque geometry and mechanical properties change during time. Blood flow is the source of biomechanical stress to the plaques. Maximum stress that atherosclerosis plaque can burden before its rupture depends on fibrous cap thickness, lipid core, calcification, and artery stenosis. When atherosclerotic plaque ruptures, the blood would be in contact with coagulation factors. That is why plaque rupture is one of the main causes of fatality.
methodIn this article, the coronary artery was modeled by ANSYS. First, fibrous cap thickness was increased from 40 μm to 250 μm by keeping other parameters constant. Then, the lipid pool percentage was incremented from 10% to 90% by keeping other parameters unchanged. Furthermore, for investigating the influence of calcium in plaque vulnerability, calcium was modeled in both agglomerated and microcalcium form.
resultsIt is proved that atherosclerosis plaque stress decreases exponentially as cap thickness increases. Larger lipid pool leads to more vulnerable plaques. In addition, the analysis showed maximum plaque stress usually increases in calcified plaque as compared with noncalcified plaque.
conclusionThe plaque stress is dependent on whether calcium is agglomerated near the lumen or far from it. However, in both cases, the deposition of more calcium in calcified plaque reduces maximum plaque stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.