Evidence map›Paper›PMID 33575003›Full record

ReviewJournal of clinical and experimental dentistry2021

Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic review.

Bianca L Cavalcante-Leão, Cristiano-Miranda de Araujo, Isabela-Bittencourt Basso, Angela-Graciela-Deliga Schroder, Odilon Guariza-Filho, Glória-Cortz Ravazzi, Flavio-Magno Gonçalves, Bianca-Simone Zeigelboim, Rosane-Sampaio Santos, José Stechman-Neto

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 6 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bianca L Cavalcante-LeãoPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Cristiano-Miranda de AraujoPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Isabela-Bittencourt BassoPostgraduate Program in Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
Angela-Graciela-Deliga SchroderPostgraduate Program in Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
Odilon Guariza-FilhoDepartment of Orthodontics, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
Glória-Cortz RavazziPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Flavio-Magno GonçalvesPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Bianca-Simone ZeigelboimPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Rosane-Sampaio SantosPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
José Stechman-NetoPostgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Brazil.
Universidade Tuiuti do Paraná · BRPontifícia Universidade Católica do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this research is to verify whether there is evidence in the literature regarding the decrease in viral load present in saliva after using three types of mouthwashes. MATERIAL AND

methodsClinical and/or

resultsThe selection of articles was carried out in two phases by two independent reviewers. After removing duplicate articles, 1245 references were maintained, and 2 articles were included in the Systematic Review. Both studies were performed in vitro and tested the virucidal action of the PVP-I solution for mouthwash at two different concentrations, 1% without dilution and 7% with 1:30 dilution, on the SARS-CoV and MERS-CoV viruses. Both showed a viral reduction of ≥ 99.99% with 15 s exposure.

conclusionsBased on the evidence currently available in the literature, PVP-I, at concentrations of 1 and 7%, appears to be the most effective mouthwash for reducing the viral load of COVID-19 present in human saliva. However, the guidelines for dental care refer to the use of hydrogen peroxide but there is insufficient scientific evidence to support this recommendation.

Identifiers

PMID33575003
PMCPMC7864359
OpenAlexW3120717280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.