ArticleJournal of clinical and experimental dentistry2021
Interventions for the treatment of xerostomia: A randomized controlled clinical trial.
Article in Journal of clinical and experimental dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Efficacy of Manuka honey oral rinse in treatment of xerostomia among elderly patients: a randomized controlled trial.BMC oral health · 2025Trial
- Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Trial
- Polypharmacy, salivary function, and oral health outcomes in institutionalized older adults: A scoping review.Journal of clinical and experimental dentistry · 2026Review
- Age, Dental State and General Health as Risk Factors for Xerostomia and Hyposalivation.International journal of dentistry · 2026Article
- Prevalence of late xerostomia and hyposalivation with associated risk factors in survivors of head and neck cancer after radiotherapy: a multi-centric cross-sectional study.Radiation oncology (London, England) · 2025Observational
- Article
- Dental care professionals' awareness of oral dryness and its clinical management: a questionnaire-based study.BMC oral health · 2024Article
- Translation and Cross-Cultural Adaptation of an Arabic Version of the Summated Xerostomia Inventory.Cureus · 2023Article
- Treatment alternatives for dry mouth: A scoping review.Journal of clinical and experimental dentistry · 2022Article
- A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Oral Care Recommendation for Cystic Fibrosis Patients-Recommendation for Dentists.Journal of clinical medicine · 2022Article
- Efficacy and safety of two artificial saliva-based polymers containing 0.1% pilocarpine for treatment of xerostomia: A randomized clinical pilot trial.Journal of clinical and experimental dentistry · 2021Article
- Aplasia of the Major and Minor Salivary Glands: Report of a Rare Case.Journal of oral & maxillofacial researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXerostomia or dry mouth sensation corresponds to a common clinical problem that can significantly impair the oral health related quality of life (OHRQoL). Currently, there is a large variety of local agents available for the treatment of xerostomia, but there is a lack robust evidence supporting the use of one treatment over another. We aimed to compare the effectiveness of a 1% malic acid salivary stimulant spray with a 1.33% betaine-based saliva substitute mouthwash in the improvement of xerostomia. MATERIAL AND
methodsFifty-one participants with drug induced or idiopathic xerostomia were randomly allocated into three groups, two intervention and one control group (placebo). OHRQoL and severity of xerostomia were assessed with the OHIP-14sp questionnaire and a visual analogue scale (VAS) respectively. Stimulated and non-stimulated salivary flow rates before and after treatments were also measured.
resultsAll three groups reported a significantly improvement in the dry mouth sensation and non-stimulated salivary flow rates, but only the malic acid spray and the betaine-based mouthwash significantly improved the OHRQoL. There were no significant differences between both intervention groups.
conclusionsThis study provides evidence that both tested agents are comparable in improving the dry mouth sensation and OHRQoL of patients with drug induced and idiopathic xerostomia.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.