ArticlePain research & management2021
Injection of Lidocaine Alone versus Lidocaine plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation.
Article in Pain research & management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in dentistry: systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- The influence of Dexmedetomidine as an additive to local anesthetics in dental procedures: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Enhanced Analgesic Outcomes with Low-dose Dexmedetomidine and Lignocaine-Adrenaline in Pediatric Inferior Alveolar Nerve Block: A Randomized Trial.International journal of clinical pediatric dentistry · 2026Article
- The effect of preoperative tizanidine on postoperative pain and trismus following surgical removal of mandibular third molar: A randomized clinical trial.SAGE open medicine · 2026Article
- Dexmedetomidine as an adjunct to local anesthetics for impacted third molar surgery: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2025Review
- Effect of dexmedetomidine on stress and inflammatory responses in patients with nasotracheal intubation after oral and maxillofacial surgery.American journal of translational research · 2025Article
- Does dexmedetomidine combined with levobupivacaine in inferior alveolar nerve blocks among patients undergoing impacted third molar surgery control postoperative morbidity?Journal of dental anesthesia and pain medicine · 2022Article
- Dexmedetomidine Co-Administered with Lidocaine Decreases Nociceptive Responses and Trigeminal Fos Expression without Motor Dysfunction and Hypotension in a Murine Orofacial Formalin Model.Life (Basel, Switzerland) · 2022Article
- Effect of Dexmedetomidine Added to Lidocaine Cartridge on the Level of Patient Sedation, Cooperation, and Patient and Surgeon Satisfaction during Mandibular Third-Molar Extraction Surgery: A Randomized Double-Blind Controlled Trial.International journal of dentistry · 2022Article
- Estimating the Need for Sedation in Patients with Dental Anxiety and Medical Complexities Reporting to Tertiary Care Dental Hospital Using the IOSN Tool.International journal of dentistry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Administration of medications such as dexmedetomidine as a topical anesthetic has been suggested in the pain control in dentistry. This double-blind randomized control trial study evaluated postoperative pain and associated factors following impacted third molar extraction surgery. Lidocaine alone was taken as the control and lidocaine plus dexmedetomidine as the intervention. Materials and Methods: Forty patients undergoing mandibular third molar extraction entered the study and were randomly allocated to the control and interventional groups. 0.15 ml of dexmedetomidine was added to each lidocaine cartridge and the drug concentration was adjusted to 15 Results: Pain scores of the intervention group decreased significantly during the surgery and also 6, 12, and 24 hours after the surgery compared to the control group. The pain score was correlated significantly with our intervention during the surgery and also 6 and 12 hours after that (all Conclusion: In patients undergoing molar surgery, administration of a combination of dexmedetomidine and lidocaine is beneficial for the pain control.
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