ArticleCanadian respiratory journal2021
Clinical Differences between Early- and Late-Onset Asthma: A Population-Based Cross-Sectional Study.
Article in Canadian respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.Annals of medicine · 2024Pooled it
- AI-Enhanced Conversational Agents for Personalized Asthma Support in People With Asthma: Factors for Engagement, Value, and Efficacy in a Cross-Sectional Survey Study.JMIR human factors · 2026Article
- Effect of COVID-19 Disease on Serum Vitamin D Status in Children with Asthma-A Retrospective Study.Journal of clinical medicine · 2025Article
- Contribution of small airway inflammation to the development of COPD.BMC pulmonary medicine · 2024Article
- Development of a nomogram to estimate the risk of community-acquired pneumonia in adults with acute asthma exacerbations.The clinical respiratory journal · 2023Article
- Validation of Diagnostic Coding for Asthma in an Electronic Health Record System in Hong Kong.Journal of asthma and allergy · 2023Article
- Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort.EBioMedicine · 2022Article
- Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications.Metabolites · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Limited information exists about the nature of late-onset asthma (LOA) without medication intervention when compared to early-onset asthma (EOA). Our goal was to understand how EOA and LOA affect clinical and pathophysiological features. Methods: A population-based cross-sectional study was carried out in Zhongshan Hospital (Shanghai, China). EOA and LOA were based on age of diagnosis (before and after age 40 years, respectively). Clinical variables were collected with an emphasis on allergic features, analyzed, related, and compared using one-way ANOVA or Kruskal-Wallis test. Correlations between blood basophils and clinical data were evaluated by Spearman's rank test. Statistical analyses were conducted with SPSS v24.0. Results: Of a total of 12,760 adults with cough, sputum, or chest tightness, 90 subjects with EOA (mean age ± standard deviation (SD):28.73 ± 5.89), 111 with LOA (mean age ± SD: 60.25 ± 9.85), and 106 with chronic obstructive pulmonary disease (COPD) (mean age ± SD: 61.58 ± 10.95) were selected. FEV Conclusion: LOA is a distinct clinical entity from EOA. In LOA, atopy was less frequent and spirometry values were lower when compared to EOA. In EOA, blood basophils and eosinophils were significantly correlated owing to pathophysiological differences between the two forms of the disease.
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