Evidence map›Paper›PMID 33574880›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Kiwi Root Extract Inhibits the Development of Endometriosis in Mice by Downregulating Inflammatory Factors.

Tingting Liao, Shenzhi Zhao, Tong Zhou, Jiajia Song, Xianping Huang, Huiqiu Xiang, Yanyan Lin, Jiajia Chen, Zhangye Xu

Abstract read
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In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingting LiaoDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Shenzhi ZhaoWenzhou Medical University, Wenzhou 325027, China.
Tong ZhouDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Jiajia SongDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Xianping HuangDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Huiqiu XiangDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Yanyan LinDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Jiajia ChenDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Zhangye XuDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.ORCID https://orcid.org/0000-0003-4269-4488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether the kiwi root extract inhibits the development of endometriosis in mice by suppressing inflammatory factors. MATERIALS AND

methodsThe mouse model of endometriosis was induced by surgery after which the mice were continuously injected with the drug for 14 days. On the 14

resultsKiwi root extract significantly reduced endometriotic lesion volume and downregulated the proinflammatory cytokines IL-6, IL-8, IL-1

conclusionsKiwi root extract could significantly inhibit the growth of surgery-induced endometriosis in mice. Our results suggest that the kiwi root extract may inhibit the development and progression of ectopic endometrium through disruption of neovascularization and reducing inflammation, which may be beneficial in treating this common gynecological disease.

Identifiers

PMID33574880
PMCPMC7857878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.