Evidence map›Paper›PMID 33574833›Full record

ArticleFrontiers in genetics2021

Niambi Brewer, John T Fong, Deyu Zhang, Girish Ramaswamy, Eileen M Shore

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Imprinting and skeletal disorders: lessons from pseudohypoparathyroidism and related disorders.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  3. Article
  4. Contract to kill: GNAS mutation.Molecular cancer · 2025
    Review
  5. Review
  6. Targeted silencing ofFrontiers in endocrinology · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Niambi BrewerDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
John T FongDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Deyu ZhangDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Girish RamaswamyDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Eileen M ShoreDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · US

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
MOLECULAR GENETICS OF PROGRESSIVE OSSEOUS HETEROPLASIAR01AR046831 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI PIGNOLO, ROBERT JOHN, SHORE, EILEEN M · 2000 to 2015
$4.3M
Mechanobiology of Progenitor Cells in Heterotopic OssificationR01AR071399 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MAUCK, ROBERT L, SHORE, EILEEN M · 2018 to 2022
$1.6M
Regulation of cell fate decision in heterotopic ossifacationF31AR073103 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BREWER, NIAMBI · 2018 to 2019
$77k
NIAMS NIH HHS F31 AR073103NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR046831NIAMS NIH HHS R01 AR071399NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

Heterotopic ossification (HO), the formation of bone outside of the skeleton, occurs in response to severe trauma and in rare genetic diseases such as progressive osseous heteroplasia (POH). In POH, which is caused by inactivation of

Indexed as

adipose stromal cellsGnasheterotopic ossificationprogressive osseous heteroplasiasubcutaneous adipose tissue

Identifiers

PMID33574833
PMCPMC7870717
OpenAlexW3125275984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.