Evidence map›Paper›PMID 33574807›Full record

ReviewFrontiers in microbiology2021

Futuristic Non-antibiotic Therapies to Combat Antibiotic Resistance: A Review.

Manoj Kumar, Devojit Kumar Sarma, Swasti Shubham, Manoj Kumawat, Vinod Verma, Praveen Balabaskaran Nina, Devraj Jp, Santosh Kumar, Birbal Singh, Rajnarayan R Tiwari

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. A One Health Perspective onMicroorganisms · 2026
    Review
  9. Antimicrobial Resistance: How Can We Overcome the Problem?Antibiotics (Basel, Switzerland) · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Bacterial warfare at the molecular level:Current research in microbial sciences · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Manoj KumarICMR-National Institute for Research in Environmental Health, Bhopal, India.
Devojit Kumar SarmaICMR-National Institute for Research in Environmental Health, Bhopal, India.
Swasti ShubhamICMR-National Institute for Research in Environmental Health, Bhopal, India.
Manoj KumawatICMR-National Institute for Research in Environmental Health, Bhopal, India.
Vinod VermaStem Cell Research Centre, Department of Hematology, SGPGIMS, Lucknow, India.
Praveen Balabaskaran NinaDepartment of Epidemiology and Public Health, Central University of Tamil Nadu, Thiruvarur, India.
Devraj JpICMR- National Institute of Nutrition, Hyderabad, India.
Santosh KumarICMR- National Institute of Nutrition, Hyderabad, India.
Birbal SinghICAR-Indian Veterinary Research Institute, Regional Station, Palampur, India.
Rajnarayan R TiwariICMR-National Institute for Research in Environmental Health, Bhopal, India.
ICMR National Institute for Research in Environmental HealthNational Institute of Nutrition · INCentral University of Tamil Nadu · INCentre of Biomedical Research · INIndian Veterinary Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the environmental "resistome" get transferred to human and veterinary pathogens. Hence, deciphering the origin, mechanism and extreme of transfer of these genetic factors into pathogens is extremely important to develop not only the therapeutic interventions to curtail the infections, but also the strategies to avert the menace of microbial drug-resistance. Clinicians, researchers and policymakers should jointly come up to develop the strategies to prevent superfluous exposure of pathogens to antibiotics in non-clinical settings. This article highlights the present scenario of increasing antimicrobial-resistance in pathogenic bacteria and the clinical importance of unconventional or non-antibiotic therapies to thwart the infectious pathogenic microorganisms.

Indexed as

alternative therapiesantibiotic resistancedrug-resistancegene transferhealth problems

Identifiers

PMID33574807
PMCPMC7870489
OpenAlexW3125053024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.