ReviewFrontiers in physiology2020
COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology.
Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of fluid and drinking on pneumonia mortality in older adults: A systematic review and meta-analysis.Clinical nutrition ESPEN · 2022Pooled it
- Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study.American journal of otolaryngologyTrial
- Folic Acid and Endothelial Dysfunction in COVID-19.Life (Basel, Switzerland) · 2026Review
- Proteomic and metabolomic profiling of plasma reveals physiologic changes in patients with convalescent COVID-19.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Self-Reported Parosmia, Phantosmia, and Gustatory Dysfunction Among Adults with Mild-to-Moderate COVID-19: A Cross-Sectional Study in Saudi Arabia.Clinics and practice · 2025Article
- Histopathology of the tongue in a hamster model of COVID-19.BMC oral health · 2025Article
- Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome.Scientific reports · 2024Article
- Histopathology of the Tongue in a Hamster Model of COVID-19.Research square · 2024Article
- Effect of oral zinc and steroids on long COVID hyposmia and hypogeusia.SAGE open medicine · 2024Article
- Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.Molecular biology reports · 2023Article
- Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.Nutrients · 2023Review
- Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study.BMC infectious diseases · 2023Article
- Identification of Genes Associated with the Impairment of Olfactory and Gustatory Functions in COVID-19 via Machine-Learning Methods.Life (Basel, Switzerland) · 2023Article
- Coronavirus infection in chemosensory cells.Journal of neurovirology · 2023Article
- Simulation of COVID-19 symptoms in a genetically engineered mouse model: implications for the long haulers.Molecular and cellular biochemistry · 2023Article
- Article
- Molecular signatures in the progression of COVID-19 severity.Scientific reports · 2022Article
- Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters.Cellular and molecular life sciences : CMLS · 2022Article
- Eating Habits and Body Weight Changes Induced by Variation in Smell and Taste in Patients with Previous SARS-CoV-2 Infection.Nutrients · 2022Review
- A multi-country study on the impact of sex and age on oral features of COVID-19 infection in adolescents and young adults.BMC oral health · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smell and taste impairments are recognized as common symptoms in COVID 19 patients even in an asymptomatic phase. Indeed, depending on the country, in up to 85-90% of cases anosmia and dysgeusia are reported. We will review briefly the main mechanisms involved in the physiology of olfaction and taste focusing on receptors and transduction as well as the main neuroanatomical pathways. Then we will examine the current evidences, even if still fragmented and unsystematic, explaining the disturbances and mode of action of the virus at the level of the nasal and oral cavities. We will focus on its impact on the peripheral and central nervous system. Finally, considering the role of smell and taste in numerous physiological functions, especially in ingestive behavior, we will discuss the consequences on the physiology of the patients as well as management regarding food intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.