Evidence map›Paper›PMID 33574717›Full record

ArticleJournal of experimental pharmacology2021

Antimalarial Activity of Methanolic Extracts and Solvent Fractions of

Melkamu Adigo Shibeshi, Engdaw Fentahun Enyew, Getnet Mequanint Adinew, Tezera Jemere Aragaw

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. The Pan African medical journal · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Melkamu Adigo ShibeshiAwi Zone Health Department, Awi Zone, Injibara, Ethiopia.
Engdaw Fentahun EnyewDepartment of Human Anatomy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Getnet Mequanint AdinewDepartment of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID 0000-0002-2085-9627
Tezera Jemere AragawDepartment of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
University of Gondar · ETAmhara Regional Health Bureau · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria is an infectious disease-causing mortality and morbidity in children and adults. Our study planned to measure the antimalarial activity of

methods

resultsChemosuppresive effect exerted by the methanolic crude extract ranged between 27 and 68%, chloroform fraction 52.93-67.73%, hexane fraction 23.61-44.97%, and aqueous fraction 29.48-51.13%. The curative effect of the crude extract was within the range of 25-49%, chloroform fraction 42.78-69.22%, and prophylactic effect of the crude extract was within the range of 51-76.2%% and chloroform fraction 46.57-71.96%. The utmost effect in all tests on chemosuppresive, curative, prophylactic, prevention of weight loss, temperature and packed cell volume, and an increase in mean survival time was observed at higher doses of the crude extract.

conclusionFrom this study, it will be concluded that crude extract of

Indexed as

antimalarialCombretum mollecrude extractPlasmodium bergheisubacute toxicity

Identifiers

PMID33574717
PMCPMC7872902
OpenAlexW3128309820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.