Evidence map›Paper›PMID 33574687›Full record

Trial reportDiabetes, metabolic syndrome and obesity : targets and therapy2021

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Laine de Carvalho Guerra Pessoa Mamede, Rafaela Lira Formiga Cavalcanti de Lima, Alexandre Sérgio Silva, João Carlos Lima Rodrigues Pita, Nadjeanny Ingrid Galdino Gomes, Elisama Araújo de Sena, Rhayra Priscila Moraes Nobrega, João Otávio Scarano Alcântara, Julie Hanna Fontes de Souza, Glêbia Alexa Cardoso and 2 more

Open access · goldAbstract readCase ReportsClinical Trial
In one paragraph

Trial report in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Laine de Carvalho Guerra Pessoa MamedePost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0001-8636-8356
Rafaela Lira Formiga Cavalcanti de LimaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0003-1272-0067
Alexandre Sérgio SilvaPost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0003-3576-9023
João Carlos Lima Rodrigues PitaHealth Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-2823-3215
Nadjeanny Ingrid Galdino GomesPost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-6367-2176
Elisama Araújo de SenaPost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
Rhayra Priscila Moraes NobregaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
João Otávio Scarano AlcântaraDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0001-7005-8302
Julie Hanna Fontes de SouzaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
Glêbia Alexa CardosoHealth Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0003-4822-1673
José Luiz de Brito AlvesPost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
Maria da Conceição Rodrigues GonçalvesPost-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-7885-4837
Universidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D.

methodsTwenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention.

resultsAnthropometric variables (waist circumference, waist-hip ratio, waist-height ratio and body mass index) were similar between groups (

conclusionIn summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.

Indexed as

inflammationlipid peroxidationobesityvitamin D

Identifiers

PMID33574687
PMCPMC7871878
OpenAlexW3128781437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.