ArticleNature immunology2021
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8
Erratum issuedOpen access · greenAbstract read
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Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 123 papers.
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123citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
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Who cites it
123 citing papers in PubMed, 188 citations in OpenAlex.
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- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Monocyte Dll4 Contributes to Systemic Inflammation in People Living With HIV.Circulation research · 2026Article
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- A community machine learning challenge to predict the effects of gene perturbations on T cell differentiation for cancer immunotherapy.bioRxiv : the preprint server for biology · 2026Article
- Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.Immunity · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- DADA Enhances CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Article
- Dynamic regulation of BACH2 enhances CAR T cell function.Molecular therapy. Oncology · 2026Article
- CAR-T cell exhaustion in B cell lymphoma: Current status, mechanisms, and potential solutions.Molecular therapy. Oncology · 2026Review
- BACH2 ameliorates cell apoptosis and autophagy as a molecular switch of BCL-2/Beclin-1 complex in myocardial infarction.Apoptosis : an international journal on programmed cell death · 2026Article
- Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma.BMC medicine · 2026Article
- Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy.Nature immunology · 2026Article
- BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.Nature immunology · 2026Article
- BACH2 regulates T cell lineage state to enhance CAR T cell function.Nature immunology · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Single-Cell RNA-Seq Profiling of Transposable Element Expression in Human Peripheral Blood Cells During Viral Infections.International journal of molecular sciences · 2026Article
- The Potential of the Gut Microbiota and Butyrate to Enhance CAR T-cell Therapy in Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
22 authors at 7 institutions in 3 countries.
Chen Yao *Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. chen.yao2@nih.gov.ORCID http://orcid.org/0000-0001-6852-5661
Guohua Lou *Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hong-Wei SunMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9765-6505
Ziang ZhuDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yi SunDepartment of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zeyu ChenDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.
Daniel ChaussImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
E Ashley MosemanDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Jun ChengNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Marc A D'AntonioDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Wangke ShiDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Junwei ShiDepartment of Cancer Biology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8427-6316
Kohei KometaniLaboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Tomohiro KurosakiLaboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID http://orcid.org/0000-0002-6352-304X
E John WherryDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0477-1956
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Luca GattinoniRegensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0003-2239-3282
Yuwen ZhuDepartment of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9568-545X
John J O'SheaMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Pamela L SchwartzbergNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Tuoqi WuDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. tuoqi.wu@cuanschutz.edu.ORCID http://orcid.org/0000-0002-4003-1034
National Institutes of Health · USUniversity of Colorado Anschutz Medical Campus · USRIKEN Center for Integrative Medical Sciences · JPTranslational Therapeutics (United States) · USDuke University · USUniversity of Pennsylvania · USUniversity of Regensburg · DE
Funding
Stat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI E. John Wherry · 2009 to 2026
$48.1MPathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6MMechanisms Underlying Clearance of the Persistently Infected CNSZIANS003111 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.0MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8MNHGRI/DIR Embryonic Stem Cell and Transgenic Mouse CoreZICHG200349 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BURGESS, SHAWN M · 2010 to 2025
$23.8MUnravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3MGenetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte SignalingZIAAI001240 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZBERG, PAMELA · 2019 to 2025
$18.8MSequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2019
$12.0MRadiation and checkpoint blockade for cancer immune therapyP01CA210944 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KOUMENIS, CONSTANTINOS · 2017 to 2022
$11.5MP3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI LUSTER, ANDREW · 2014 to 2018
$9.8MProgramming T Cell Fates for Therapeutic UseZIABC011480 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GATTINONI, LUCA · 2013 to 2019
$7.4MIntramural NIH HHS ZIA AI001240Intramural NIH HHS ZIA AI001241Intramural NIH HHS ZIA AR041106Intramural NIH HHS ZIA AR041159Intramural NIH HHS ZIA AR041167Intramural NIH HHS ZIA BC011480Intramural NIH HHS ZIA DK075149Intramural NIH HHS ZIA NS003111Intramural NIH HHS ZIA NS003112NCI NIH HHS F99 CA234842NCI NIH HHS K00 CA234842NCI NIH HHS P01 CA210944NIAID NIH HHS P01 AI108545NIAID NIH HHS P01 AI112521NIAID NIH HHS R01 AI105343NIAID NIH HHS R01 AI115712NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI117950NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524
Abstract
During chronic infection and cancer, a self-renewing CD8
Indexed as
Cell DifferentiationEpigenesis, GeneticTranscription, GeneticAnimalsArenaviridae InfectionsBasic-Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesCell LineageCells, CulturedChronic DiseaseDisease Models, AnimalHost-Pathogen InteractionsLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutBach2 protein, mouseBasic-Leucine Zipper Transcription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.