ArticleNature methods2021
Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning.
Article in Nature methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 226 citations in OpenAlex.
- NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamicsbioRxiv : the preprint server for biology · 2026Article
- Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets.Nature methods · 2026Article
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Photonics Breakthroughs 2025: Mask-Based Integrated Miniscope for Large-scale Volumetric Imaging.IEEE photonics journal · 2026Article
- High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo.Nature biotechnology · 2026Article
- Foveated light-field compound imager.Science advances · 2026Article
- Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.Scientific reports · 2026Article
- High-speed whole-brain imaging in Drosophila.Nature communications · 2026Article
- High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics.Nature biotechnology · 2026Article
- Single-shot extended-depth-of-field fourier light field microscopy enabled by a distorted grating.Biomedical optics express · 2026Article
- Foveated Light-Field Compound Imager.bioRxiv : the preprint server for biology · 2026Article
- Patch deconvolution for Fourier light-field microscopy.Biophysical journal · 2026Article
- Improved 3D image reconstruction via deep-learning-based fusion of light-field microscopy and Fourier light-field microscopy images.Journal of biomedical optics · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Curvy Surface Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Emerging Light-Sheet Fluorescence Microscopy for Cardiac Vascular Imaging in Zebrafish.Current treatment options in cardiovascular medicine · 2026Review
- Snapshot 3D at the speed frontier: redefining light-field microscopy for neuroimaging.PhotoniX · 2026Article
- Volumetric localization microscopy with deep learning.Nature communications · 2025Article
- Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Light-field microscopy has emerged as a technique of choice for high-speed volumetric imaging of fast biological processes. However, artifacts, nonuniform resolution and a slow reconstruction speed have limited its full capabilities for in toto extraction of dynamic spatiotemporal patterns in samples. Here, we combined a view-channel-depth (VCD) neural network with light-field microscopy to mitigate these limitations, yielding artifact-free three-dimensional image sequences with uniform spatial resolution and high-video-rate reconstruction throughput. We imaged neuronal activities across moving Caenorhabditis elegans and blood flow in a beating zebrafish heart at single-cell resolution with volumetric imaging rates up to 200 Hz.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.