ArticleScientific reports2021
Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Microfluidic Gratings for X-Ray Phase Contrast Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- X-ray histology on rapidly fixed fresh tumor tissue samples for fast resection margin assessment.Scientific reports · 2026Article
- Advancing three-dimensional tendon imaging using laboratory X-ray phase contrast techniques and refined sample preparation.Scientific reports · 2026Article
- Multi-contrast X-ray microtomography of human lung specimens with an extended field-of-view.Medical physics · 2026Article
- Simultaneous signal optimization of refraction and attenuation in x-ray grating interferometry: A case study for breast imaging.Medical physics · 2025Article
- Phase contrast micro-CT with adjustable in-slice spatial resolution at constant magnification.Physics in medicine and biology · 2024Article
- T staging esophageal tumors with x rays.Optica · 2024Article
- Neodymium acetate as a contrast agent for X-ray phase-contrast tomography.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Article
- Edge-Illumination X-Ray Dark-Field Tomography.Physical review applied · 2023Article
- Emerging and future use of intra-surgical volumetric X-ray imaging and adjuvant tools for decision support in breast-conserving surgery.Current opinion in biomedical engineering · 2022Article
- Can laboratory x-ray virtual histology provide intraoperative 3D tumor resection margin assessment?Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Volumetric High-Resolution X-Ray Phase-Contrast Virtual Histology of Breast Specimens With a Compact Laboratory System.IEEE transactions on medical imaging · 2022Article
- Iterative phase contrast CT reconstruction with novel tomographic operator and data-driven prior.PloS one · 2022Article
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection of margin involvement intraoperatively would allow the removal of additional tissue during the same intervention. X-ray phase contrast imaging (XPCI) provides soft tissue sensitivity superior to conventional X-rays: we propose its use to detect margin involvement intraoperatively. We have developed a system that can perform phase-based computed tomography (CT) scans in minutes, used it to image 101 specimens approximately half of which contained neoplastic lesions, and compared results against those of a commercial system. Histological analysis was carried out on all specimens and used as the gold standard. XPCI-CT showed higher sensitivity (83%, 95% CI 69-92%) than conventional specimen imaging (32%, 95% CI 20-49%) for detection of lesions at margin, and comparable specificity (83%, 95% CI 70-92% vs 86%, 95% CI 73-93%). Within the limits of this study, in particular that specimens obtained from surplus tissue typically contain small lesions which makes detection more difficult for both methods, we believe it likely that the observed increase in sensitivity will lead to a comparable reduction in the number of re-operations.
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