ArticleNature plants2021
A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 111 citations in OpenAlex.
- Diverse haplotypes at a complex Solanum americanum locus confer resistance to Phytophthora infestans and P. capsici.The Plant cell · 2026Article
- Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026Review
- A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.Science advances · 2026Article
- Article
- Genome editing of susceptibility geneFrontiers in plant science · 2026Article
- The Application of RenSeq for Pan-NLRome Analysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Late blight field resistance in potatoes carryingGM crops & food · 2025Article
- Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity.Nature communications · 2025Article
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in Nicotiana benthamiana prf mutants.Plant physiology · 2025Article
- Multiple effectors trigger non-host resistance in Solanum americanum against Pseudomonas syringae.The Plant journal : for cell and molecular biology · 2025Article
- Structural Insights Into the Role of RxLR Effectors in the Arms Race Between Oomycetes and Plants.Molecular plant pathology · 2025Review
- Deciphering the Molecular Interplay Between RXLR-EncodedInternational journal of molecular sciences · 2025Review
- Host-induced gene silencing of the amino acid biosynthesis gene acetolactate synthase of Phytophthora infestans caused strong enhanced late blight resistance of potato in the field.Plant biotechnology journal · 2025Article
- Assembly and annotation of Solanum dulcamara and Solanum nigrum plant genomes, two nightshades with contrasting susceptibilities to Ralstonia solanacearum.G3 (Bethesda, Md.) · 2025Article
- Expression of a modified Avr3a gene under the control of a synthetic pathogen-inducible promoter leads to Phytophthora infestans resistance in potato.Plant biotechnology journal · 2025Article
- Patterns of presence-absence variation of NLRs across populations of Solanum chilense are clade-dependent and mainly shaped by past demographic history.The New phytologist · 2025Article
- Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants.Nature communications · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 7 countries.
Funding
Abstract
Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains elusive. We positionally cloned a new R gene, Rpi-amr1, from Solanum americanum, that encodes an NRC helper-dependent CC-NLR protein. Rpi-amr1 confers resistance in potato to all 19 P. infestans isolates tested. Using association genomics and long-read RenSeq, we defined eight additional Rpi-amr1 alleles from different S. americanum and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize Avramr1 orthologues and paralogues. We propose that Rpi-amr1 gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against P. infestans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.