ArticleScientific reports2021
Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Systematic review and meta-analysis of risk factors for erectile dysfunction after stroke: a Mendelian randomization approach.Sexual medicine · 2026Article
- Environmental and microbiome determinants of sperm quality: a narrative review on male health.Translational andrology and urology · 2026Review
- Dose-Dependent Effects of Intratesticular Adipose-Derived Mesenchymal Stem Cell Injection on Heat-Induced Spermatogenesis Disorder in Wistar Rats: Focus on Apoptosis and Oxidative Stress.Iranian journal of pathology · 2026Article
- Article
- Pathological and vascular changes in the rat testiсle after experimental trauma.Clinical and experimental reproductive medicine · 2025Article
- Preventive administration of shengmaiyin: a novel approach to counteract heatstroke-induced coagulopathy in rats.Frontiers in pharmacology · 2025Article
- Public knowledge, attitudes, and practices toward heat stroke in Ningbo, China: a cross-sectional study.Frontiers in public health · 2025Article
- Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke.Journal of nanobiotechnology · 2024Article
- Endocrine effects of heat exposure and relevance to climate change.Nature reviews. Endocrinology · 2024Review
- The significant mechanism and treatments of cell death in heatstroke.Apoptosis : an international journal on programmed cell death · 2024Review
- Heat-related illness and dementia: a study integrating epidemiological and experimental evidence.Alzheimer's research & therapy · 2024Article
- Coat color affects the resilience against heat stress impacts on testicular hemodynamics, reproductive hormones, and semen quality in Baladi goats.BMC veterinary research · 2023Article
- Transcriptome Analysis in High Temperature Inhibiting Spermatogonial Stem Cell Differentiation In Vitro.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Optimizing a mouse model of exertional heat stroke to simulate multiorgan and brain injuries.Brain circulationArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate.
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