Evidence map›Paper›PMID 33574462›Full record

ArticleScientific reports2021

Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis.

Owen Dean, Seher Anjum, Terri Scott, Lillian Ham, Katherine Traino, Jing Wang, Sally Hunsberger, John H Powers, Kieren A Marr, Joseph Snow and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical Outcome Assessments in Encephalitis: A Systematic ReviewNeurology(R) neuroimmunology & neuroinflammation · 2024
    Pooled it
  2. Cryptococcal meningitis.Nature reviews. Disease primers · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Owen DeanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 10, Rm 11C208, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Seher AnjumLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 10, Rm 11C208, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Terri ScottLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 10, Rm 11C208, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Lillian HamNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Katherine TrainoNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Jing WangClinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Sally HunsbergerBiostatistics Research Branch, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
John H PowersClinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Kieren A MarrJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Joseph SnowNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Peter R WilliamsonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 10, Rm 11C208, 9000 Rockville Pike, Bethesda, MD, 20892, USA. williamsonpr@mail.nih.gov.

Funding

Molecular Pathobiology of Cryptococcus neoformansZIAAI001123 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WILLIAMSON, PETER · 2010 to 2025
$10.4M
Translational Research: Host-Pathogen Interactions in Patient Fungal DiseasesZIAAI001124 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WILLIAMSON, PETER · 2010 to 2025
$8.8M
Prospective Cohort Study of CryptococcosisU01AI109657 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MARR, KIEREN A., WILLIAMSON, PETER RICHARD · 2013 to 2015
$1.9M
NIAID NIH HHS U01 AI109657NIAID NIH HHS UO1 AI109657
6 · The paper itself

Abstract

The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.

Indexed as

AdultCohort StudiesCryptococcus neoformansFemaleHealth StatusHIVHIV InfectionsHumansMaleMeningitis, CryptococcalMiddle AgedQuality of Life

Identifiers

PMID33574462
PMCPMC7878796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.