Evidence map›Paper›PMID 33574451›Full record

ArticleScientific reports2021

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity.

Sari Niinistö, Iris Erlund, Hye-Seung Lee, Ulla Uusitalo, Irma Salminen, Carin Andrén Aronsson, Hemang M Parikh, Xiang Liu, Sandra Hummel, Jorma Toppari and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Latent autoimmune diabetes in youth.Frontiers in immunology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Sari NiinistöHealth and Well-Being Promotion Unit, Public Health and Welfare Department, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland. sari.niinisto@thl.fi.
Iris ErlundDepartment of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.
Hye-Seung LeeHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
Ulla UusitaloHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
Irma SalminenDepartment of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.
Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, CRC, Skåne University Hospital, Malmö, Sweden.
Hemang M ParikhHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
Xiang LiuHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
Sandra HummelInstitute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum Rechts Der Isar, Technische Universität München and Forschergruppe Diabetes e.V., Munich, Germany.
Jorma ToppariDepartment of Physiology, University of Turku, Turku, Finland.
Jin-Xiong SheHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
Åke LernmarkDepartment of Clinical Sciences, Lund University, CRC, Skåne University Hospital, Malmö, Sweden.
Annette G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum Rechts Der Isar, Technische Universität München and Forschergruppe Diabetes e.V., Munich, Germany.
Marian RewersBarbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, USA.
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jeffrey P KrischerHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.
David GalasPacific Northwest Research Institute, Seattle, WA, USA.
Siba DasPacific Northwest Research Institute, Seattle, WA, USA.
Nikita SakhanenkoPacific Northwest Research Institute, Seattle, WA, USA.
Stephen S RichUniversity of Virginia School of Medicine, Virginia, USA.
William HagopianPacific Northwest Research Institute, Seattle, WA, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, USA.
Suvi M VirtanenHealth and Well-Being Promotion Unit, Public Health and Welfare Department, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
TEDDY Study Group

Funding

NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4M
The Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0M
The Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5M
THE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
NIDDK NIH HHS P30 DK116073NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063863NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483
6 · The paper itself

Abstract

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n - 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.

Indexed as

AutoimmunityBreast FeedingCase-Control StudiesChildChild, PreschoolErythrocytesFatty AcidsFemaleHumansInfantIslets of LangerhansMaleRisk FactorsFatty Acids

Identifiers

PMID33574451
PMCPMC7878879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.