ArticleScientific reports2021
Use of multiple metrics to assess antibiotic use in Italian children's hospitals.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Trajectories of antibiotic prescriptions in Italian children in the first four years of life: a retrospective birth-cohort study.BMC public health · 2026Article
- Monitoring of pediatric antibiotic consumption using electronic medical records in an Italian tertiary care hospital.Scientific reports · 2025Article
- Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland.Children (Basel, Switzerland) · 2024Article
- Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013-2020.Infection · 2024Article
- High clonal diversity of Staphylococcus aureus isolates from children's playgrounds in Hungary.Scientific reports · 2024Article
- Article
- Point prevalence survey of antibiotics use among hospitalised neonates and children in Saudi Arabia: findings and implications.Journal of pharmaceutical policy and practice · 2024Article
- Editorial for the Special Issue "Antibiotic Prescribing and Antimicrobial Resistance Patterns in Pediatric Patients".Antibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018.Antimicrobial resistance and infection control · 2023Article
- Development of Antimicrobial Defined Daily Dose (DDD) for the Pediatric Population.Antibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial Utilization among Neonates and Children: A Multicenter Point Prevalence Study from Leading Children's Hospitals in Punjab, Pakistan.Antibiotics (Basel, Switzerland) · 2022Article
- Reduction in broad-spectrum antimicrobial prescriptions by primary care pediatricians following a multifaceted antimicrobial stewardship program.Frontiers in pediatrics · 2022Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantification of antibiotic utilization is an essential component of antibiotic stewardship programs. In this multicentric study, we used different metrics to evaluate inpatient antibiotic use in children. The study objectives were to describe point prevalence of antibiotic use by indication and patient characteristics, to evaluate DOTs, LOTs and PDDs, and to compare PDDs to DDDs, which assume average maintenance dose per day in adults. All children hospitalized on the days of the study were included. Trained personnel collected demographic and clinical data from patients' clinical records. We recorded information about antibiotics administered on the date of data collection, and in the previous 30 days of hospitalization. Of 810 patients, 380 (46.9%; CI 95%: 43.4-50.4) received one or more antibiotics; prevalence of use was 27.0% for prophylaxis (219/810), and 20.7% (168/810) for treatment. Overall, 587 drugs were issued to the 380 patients receiving antibiotics (1.5 antibiotic per patient). When considering treatments, DOT and LOT per 100 patient-days were 30.5 and 19.1, respectively, resulting in a DOT/LOT ratio of 1.6. PDDs increased with age and approached DDDs only in children aged ≥ 10 years; the ratio between PDDs estimated in children aged ≥ 10 years and in 0-11 month-old infants ranged from 2 for sulfamethoxazole and trimethoprim, to 25 for meropenem. Our results confirm that DOT, LOT and PDD are better alternatives to DDD in children.
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