ArticleScientific reports2021
A retrospective study of hypofractionated radiotherapy for keloids in 100 cases.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Therapeutic methods and effect on keloid and hypertrophic scars: a systematic review.Frontiers in medicine · 2026Pooled it
- Alternative treatment for recurrent keloids: initial clinical experience with Rhenium-188 using a specialized device.European journal of nuclear medicine and molecular imaging · 2025Trial
- Hydrogel microneedles functioning in pathological surroundings: where soft materials overcome hard scars.Materials today. Bio · 2026Review
- Visual outcomes of sight threatening radiation-induced meningiomas after low-dose head irradiation: tinea capitis as a paradigm.Journal of neuro-oncology · 2026Article
- Efficacy of peri-operative high-dose-rate interstitial brachytherapy in keloids: Can we scare the bad scar?Journal of contemporary brachytherapy · 2026Article
- Post-surgical electron beam radiotherapy for prevention of keloid recurrence: A retrospective study of 619 cases demonstrating low recurrence (6.5%) with optimised 18 Gy in two fractions.Clinical medicine (London, England) · 2026Article
- Application of Brachytherapy in Postoperative Treatment of Keloid-Prone Patients.Journal of cosmetic dermatology · 2026Article
- Punch Excision Combined With Radiotherapy for Keloid Treatment.Journal of cosmetic dermatology · 2026Article
- Efficacy and Safety of Punch Excision Combined With Adjuvant Therapies for Hypertrophic Scars and Keloids: A Narrative Review.Journal of cosmetic dermatology · 2026Review
- Combining Steroid Plus 5-Fluorouracil Injection with Radiotherapy Versus Injection Alone for Keloids: A 4-Year Retrospective Study.Aesthetic plastic surgery · 2025Article
- Ear Keloids Treated with Postoperative Electrons: A Case Series.South Asian journal of cancer · 2025Article
- Review
- Treatment outcomes of surgery followed by short-course every other day radiotherapy in keloid.Radiation oncology (London, England) · 2024Article
- Successful treatment of Giant keloid on the right toes using trepanation combined with superficial radiotherapy (SRT-100): a case report with literature review.Frontiers in medicine · 2024Review
- Treatment of Keloids with Surgery and Immediate Postoperative Radiotherapy: Knowledge Gained Over 17 Years.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2023Article
- Progress in the clinical treatment of keloids.Frontiers in medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, the consensus on the best treatment for keloids is the combination of clinical and surgical therapies, if necessary, associated with adjuvant radiotherapy like brachytherapy. Whereas, the uniform scheme of radiotherapy in keloids is unclear. Here, we conducting a retrospective analysis to assess the efficacy and safety of a specific treatment regimen (20 Gy in 5 fractions) in keloid patients. We retrospectively analysed the medical records of keloid patients receiving auxiliary postoperative radiotherapy (PORT) treatment from 2009 to 2019. The patients were treated with the hypofractionation method of 20 Gy in 5 fractions. We compared the local control rate and complications, using the chi-square test and logistic regression analyses. After screening, we identified 100 keloid patients in this study, with a median follow-up of 59 months. In this study, the overall local control rate of keloid lesions was 84.8%. After multivariate analyses (primary keloid or not, family history, interval from surgery to irradiation and site), our research showed that primary keloid, site and interval from surgery to irradiation were significantly related to recurrence. Acute radiation injury and late radiation injury accounted for 3% (erythema) and 1% (skin sclerosis) of the total cases, respectively. Our results indicate that a postoperative hypofractionation with radiation dose of 20 Gy in 5 fractions may be effective, easy to accept and safe for keloid patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.