Evidence map›Paper›PMID 33574405›Full record

ArticleScientific reports2021

Feasibility and safety study of a high resolution wide field-of-view scanning endoscope for circumferential intraluminal intestinal imaging.

Lily L Lai, Marta Invernizzi, Michael White, Chao Han, Huangfu Jiangtao, Helen Lu, Changhuei Yang, James Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lily L LaiDepartment of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. llai@coh.org.
Marta InvernizziDepartment of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
Michael WhiteDepartment of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.
Chao HanDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Huangfu JiangtaoDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Helen LuDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Changhuei YangDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
James LinDepartment of Gastroenterology, City of Hope, Duarte, CA, USA.
California Institute of Technology · USCity of Hope · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global anal cancer incidence is increasing. High resolution anoscopy (HRA) currently screens for anal cancer, although the definitive test remains unknown. To improve on intraluminal imaging of the anal canal, we conducted a first-in-human study to determine feasibility and safety of a high-resolution, wide field-of-view scanning endoscope. Fourteen patients, under an IRB-approved clinical study, underwent exam under anesthesia, HRA, and imaging with the experimental device. HRA findings were photographed using an in-line camera attached to the colposcope and compared with the scanning endoscope images. Patients were followed up within 2 weeks of the procedure. The imaging device is inserted into the anal canal and the intraluminal surface is digitally photographed in 10 s and uploaded to a computer monitor for review. Ten patients completed imaging with the device. Three patients were not imaged due to severe anal stenosis. One patient was not imaged due to technical device malfunction. The device images were compared to the HRA images. No adverse event attributable to the device was reported. The intraluminal scanning endoscope can be used for circumferential anal canal imaging and is safe for clinical use. Future clinical studies are needed to evaluate the performance of this device.

Indexed as

Early Detection of CancerEndoscopes, GastrointestinalAgedAnal CanalAnus DiseasesColposcopesDiagnostic ImagingFeasibility StudiesFemaleHumansIntestinesMaleMiddle AgedPrecancerous Conditions

Identifiers

PMID33574405
PMCPMC7878729
OpenAlexW3126970187

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.