ArticleNature communications2021
Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- 3D DNA origami-enabled molecularly addressable optical nanocircuit.Science advances · 2026Article
- Advances in DNA nanostructures for pathogenic microorganisms.Materials today. Bio · 2026Review
- Nanorulers for Super-Resolution Microscopy.Chembiochem : a European journal of chemical biology · 2026Review
- All-inorganic perovskites for four-dimensional dynamic encryption.Science advances · 2026Article
- DNA-programmed galvanic Ostwald ripening in nanoparticle assemblies.Nature communications · 2026Article
- Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.ACS sensors · 2026Article
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- Deep Learning Integration in Optical Microscopy: Advancements and Applications.Microscopy research and technique · 2026Review
- Single-Molecule Imaging and Spectroscopy Enables Quantification of Location-Dependent Light-Matter Interactions on Nanoantennas.Small science · 2026Article
- DNA Nanostructure-Assembled Metallic Nanoparticles for Biosensing Applications.Molecules (Basel, Switzerland) · 2026Review
- High-Throughput Fabrication of Zero-Mode Waveguide Nanoaperture Arrays with Sol-Gel Nanoimprint Lithography for Enhanced Single Molecule Fluorescence Detection.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.bioRxiv : the preprint server for biology · 2025Article
- Review
- Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope.Nature communications · 2025Article
- Bringing Attomolar Detection to the Point-of-Care with Nanopatterned DNA Origami Nanoantennas.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- DNAzyme-driven dual-cycle coupled with pregnancy test strip signal transduction for monitoring of Dreissena polymorpha.Mikrochimica acta · 2025Article
- Label-free (fluorescence-free) sensing of a single DNA molecule on DNA origami using a plasmon-enhanced WGM sensor.Nanophotonics (Berlin, Germany) · 2025Article
- Engineering modular and tunable single-molecule sensors by decoupling sensing from signal output.Nature nanotechnology · 2025Article
- Recent Advances in DNA Origami-Enabled Optical Biosensors for Multi-Scenario Application.Nanomaterials (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
The advent of highly sensitive photodetectors and the development of photostabilization strategies made detecting the fluorescence of single molecules a routine task in many labs around the world. However, to this day, this process requires cost-intensive optical instruments due to the truly nanoscopic signal of a single emitter. Simplifying single-molecule detection would enable many exciting applications, e.g., in point-of-care diagnostic settings, where costly equipment would be prohibitive. Here, we introduce addressable NanoAntennas with Cleared HOtSpots (NACHOS) that are scaffolded by DNA origami nanostructures and can be specifically tailored for the incorporation of bioassays. Single emitters placed in NACHOS emit up to 461-fold (average of 89 ± 7-fold) brighter enabling their detection with a customary smartphone camera and an 8-US-dollar objective lens. To prove the applicability of our system, we built a portable, battery-powered smartphone microscope and successfully carried out an exemplary single-molecule detection assay for DNA specific to antibiotic-resistant Klebsiella pneumonia on the road.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.