ArticleNature communications2021
Silane- and peroxide-free hydrogen atom transfer hydrogenation using ascorbic acid and cobalt-photoredox dual catalysis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 128 citations in OpenAlex.
- Acetylene Semi-Hydrogenation by Photocatalysis.Angewandte Chemie (International ed. in English) · 2026Review
- Cobaltaphotocatalysed intramolecular hydroarylation of alkenes for the construction of tetrahydroquinolines.Chemical science · 2026Article
- Dual Photoredox/Cobalt Catalysis Enabled Regiospecific Markovnikov Hydroboration of Unactivated Mono-, Di-, and Trisubstituted Alkenes.Nature communications · 2026Article
- A Dual Photoredox/Cobalt Catalytic System Enables Markovnikov-Selective Hydroaminoalkylation of Alkenes.Precision chemistry · 2026Article
- Asymmetric Reduction of Unactivated Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Spatiotemporally ordered topological transformation in layered double hydroxides enables synergistic mineralization of AsNature communications · 2026Article
- One-Electron Approach for Trans-Selective Alkyne Semi-Reduction via Cobalt Catalysis.Journal of the American Chemical Society · 2025Article
- Unlocking nucleophilic reactivity in Co-MHAT catalysis: Stereospecific backside-backside displacement by anion-activated organocobalt.Science advances · 2025Article
- Article
- Kinetic Resolution of Heterocyclic Lactams by a Photocatalytic Cobalt-Catalyzed Dehydrogenation.Journal of the American Chemical Society · 2025Article
- Fluorinated Radicals in Divergent Synthesis via Photoredox Catalysis.Accounts of chemical research · 2025Article
- Merging Hydrogen-Atom-Transfer and the Truce-Smiles Rearrangement for Synthesis of β-Arylethylamines from Unactivated Allylsulfonamides.Angewandte Chemie (International ed. in English) · 2025Article
- Photo- and Cobalt-Catalyzed Cycloisomerization of Unsaturated Guanidines, (Iso-)Ureas, and Carbonates.Organic letters · 2025Article
- Photocatalytic Semi-Hydrogenation of Acetylene to Polymer-Grade Ethylene with Molecular and Metal-Organic Framework Cobaloximes.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Electrochemically Determined and Structurally Justified Thermochemistry of H atom Transfer on Ti-Oxo Nodes of the Colloidal Metal-Organic Framework Ti-MIL-125.Journal of the American Chemical Society · 2024Article
- Shuttle HAT for mild alkene transfer hydrofunctionalization.Nature communications · 2024Article
- Fluorescence and colorimetric rapid dual-signal "on-off-on" switching detection of ascorbic acid based on TSPP/DCIP.Mikrochimica acta · 2024Article
- Harnessing the potential of acyl triazoles in bifunctional cobalt-catalyzed radical cross-coupling reactions.Nature communications · 2024Article
- Divergent functionalization of alkenes enabled by photoredox activation of CDFA and α-halo carboxylic acids.Chemical science · 2024Article
- Quantum chemical calculations for reaction prediction in the development of synthetic methodologies.Chemical science · 2023Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen atom transfer (HAT) hydrogenation has recently emerged as an indispensable method for the chemoselective reduction of unactivated alkenes. However, the hitherto reported systems basically require stoichiometric amounts of silanes and peroxides, which prevents wider applications, especially with respect to sustainability and safety concerns. Herein, we report a silane- and peroxide-free HAT hydrogenation using a combined cobalt/photoredox catalysis and ascorbic acid (vitamin C) as a sole stoichiometric reactant. A cobalt salophen complex is identified as the optimal cocatalyst for this environmentally benign HAT hydrogenation in aqueous media, which exhibits high functional-group tolerance. In addition to its applicability in the late-stage hydrogenation of amino-acid derivatives and drug molecules, this method offers unique advantage in direct transformation of unprotected sugar derivatives and allows the HAT hydrogenation of unprotected C-glycoside in higher yield compared to previously reported HAT hydrogenation protocols. The proposed mechanism is supported by experimental and theoretical studies.
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Registered trials
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