Evidence map›Paper›PMID 33574183›Full record

ArticleScience (New York, N.Y.)2021

Comment on "Structural evidence for a dynamic metallocofactor during N

John W Peters, Oliver Einsle, Dennis R Dean, Serena DeBeer, Brian M Hoffman, Patrick L Holland, Lance C Seefeldt

Abstract readComment
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Quantum Mechanical/Molecular Mechanical (QM/MM) Studies of Enzymes.Advances in experimental medicine and biology · 2026
    Review
  5. Synthetic models of the nitrogenase FeMo cofactor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. The HD Reaction of Nitrogenase: a Detailed Mechanism.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  12. Proton Transfer Pathways in Nitrogenase with and without Dissociated S2B.Angewandte Chemie (International ed. in English) · 2022
    Article
  13. Four-Coordinate Fe NInorganic chemistry · 2022
    Article
  14. Review
  15. Review
  16. The Conversion of Carbon Monoxide and Carbon Dioxide by Nitrogenases.Chembiochem : a European journal of chemical biology · 2022
    Review
  17. A Mechanism for Nitrogenase Including Loss of a Sulfide.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  18. The EChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

John W PetersInstitute of Biological Chemistry, Washington State University, Pullman, WA 99164, USA. jw.peters@wsu.edu einsle@bio.chemie.uni-freiburg.de.ORCID https://orcid.org/0000-0001-9117-9568
Oliver EinsleInstitute of Biochemistry, Albert-Ludwigs Universität, Freiburg, Germany. jw.peters@wsu.edu einsle@bio.chemie.uni-freiburg.de.ORCID https://orcid.org/0000-0001-8722-2893
Dennis R DeanBiochemistry Department, Virginia Tech, Blacksburg, VA 24061, USA.ORCID https://orcid.org/0000-0001-8960-6196
Serena DeBeerMax Planck Institute for Chemical Energy Conversion, D-45470 Mülheim an der Ruhr, Germany.ORCID https://orcid.org/0000-0002-5196-3400
Brian M HoffmanDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID https://orcid.org/0000-0002-3100-0746
Patrick L HollandDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID https://orcid.org/0000-0002-2883-2031
Lance C SeefeldtChemistry and Biochemistry, Utah State University, Logan, UT 84322, USA.ORCID https://orcid.org/0000-0002-6457-9504

Funding

Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Low-Coordinate Synthetic Models for Nitrogenase ActivityR01GM065313 · NIGMS · YALE UNIVERSITY · PI PATRICK L HOLLAND · 2004 to 2026
$6.4M
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactionsR01GM138592 · NIGMS · WASHINGTON STATE UNIVERSITY · PI PETERS, JOHN W · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM065313NIGMS NIH HHS R01 GM111097NIGMS NIH HHS R01 GM138592
6 · The paper itself

Abstract

Kang

Indexed as

Azotobacter vinelandiiMolybdoferredoxinCatalytic DomainNitrogenaseMolybdoferredoxinNitrogenase

Identifiers

PMID33574183
PMCPMC7931246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.