ArticleScience (New York, N.Y.)2021
Reintroduction of the archaic variant of
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Genomic structural variations distinguishing archaic and modern humans are associated with neurodevelopment.iScience · 2026Article
- Spatially resolved chromatin architectures in mammalian brain tissues.Nature methods · 2026Article
- Evolution-guided yeast complementation reveals functional differences in human PSPH variants.FEBS open bio · 2026Article
- Brain organoids and genome editing: A new era in understanding human brain development and disorders.Neural regeneration research · 2026Article
- A gene therapy strategy for Deoxyhypusine Synthase (DHPS) syndrome.Research square · 2026Article
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Article
- Article
- PSVRP: a pig structural variant reference panel for complex trait genomics and precision breeding.BMC genomics · 2025Article
- Impact of intermittent lead exposure on hominid brain evolution.Science advances · 2025Article
- Deciphering brain organoid heterogeneity by identifying key quality determinants.Communications biology · 2025Article
- The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Alternative splicing in stem cells and development: research progress and emerging technologies.Cell regeneration (London, England) · 2025Review
- DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change.bioRxiv : the preprint server for biology · 2025Article
- A humanized NOVA1 splicing factor alters mouse vocal communications.Nature communications · 2025Article
- Implementation and validation of single-cell genomics experiments in neuroscience.Nature neuroscience · 2024Review
- Massively parallel approaches for characterizing noncoding functional variation in human evolution.Current opinion in genetics & development · 2024Review
- Generation of 'semi-guided' cortical organoids with complex neural oscillations.Nature protocols · 2024Review
- A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution.Development (Cambridge, England) · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 3 countries.
Cleber A TrujilloDepartment of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0002-0675-6437
Edward S RiceDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-2961-217X
Nathan K SchaeferDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0001-5881-7329
Isaac A ChaimDepartment of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-1787-046X
Emily C WheelerDepartment of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-0260-8530
Assael A MadrigalDepartment of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Justin BuchananDepartment of Cellular & Molecular Medicine, Center for Epigenomics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0001-5904-222X
Sebastian PreisslDepartment of Cellular & Molecular Medicine, Center for Epigenomics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0001-8971-5616
Allen WangDepartment of Cellular & Molecular Medicine, Center for Epigenomics, University of California, San Diego, La Jolla, CA 92093, USA.
Priscilla D NegraesDepartment of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0001-7876-1895
Ryan A SzetoDepartment of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0003-0213-4443
Roberto H HeraiExperimental Multiuser Laboratory (LEM), Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil.ORCID https://orcid.org/0000-0001-9885-2735
Alik HuseynovNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.ORCID https://orcid.org/0000-0002-1438-4389
Mariana S A FerrazLaboratório de Neurogenética, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP 09606-070, Brazil.ORCID https://orcid.org/0000-0002-5574-2840
Fernando S BorgesLaboratório de Neurogenética, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP 09606-070, Brazil.ORCID https://orcid.org/0000-0002-7647-2341
Alexandre H KiharaLaboratório de Neurogenética, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP 09606-070, Brazil.ORCID https://orcid.org/0000-0002-4027-7261
Ashley ByrneDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Maximillian MarinDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-9108-3328
Christopher VollmersDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-7626-6222
Angela N BrooksDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-7898-3073
Jonathan D LautzCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Katerina SemendeferiDepartment of Anthropology, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0002-9867-9554
Beth ShapiroDepartment of Ecology and Evolutionary Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-2733-7776
Gene W YeoDepartment of Cellular & Molecular Medicine, Center for Epigenomics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0002-0799-6037
Stephen E P SmithCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.ORCID https://orcid.org/0000-0003-4180-573X
Richard E GreenDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0003-0516-5827
Alysson R MuotriDepartment of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA. muotri@ucsd.edu.ORCID https://orcid.org/0000-0003-0867-2875
University of California San Diego · USUniversity of California, Santa Cruz · USUniversidade Federal do ABC · BRUniversity of Washington · USHoward Hughes Medical Institute · USImperial College London · GBPontifícia Universidade Católica do Paraná · BR
Funding
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4MSingle-cell approaches to deconvolution of disease-associated signalsU19MH107367 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALLAWAY, EDWARD M · 2015 to 2019
$15.0MFunctional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4MA Comprehensive Functional Map of Human Protein-RNA InteractionsU41HG009889 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2018 to 2021
$9.4MInvestigating the synaptic pathology of AutismR01MH113545 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI Stephen Edward Paucha Smith · 2018 to 2026
$5.8MA comprehensive binding and functional map of human RNA-binding proteinsU24HG009889 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R., YEO, EUGENE WEI-MING · 2022 to 2025
$5.5MAnalysis of RNA binding proteins directing hematopoietic stem cell fateR01HL137223 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPE, KRISTIN, YEO, EUGENE WEI-MING · 2018 to 2021
$2.5MSubtyping the autisms using individualized protein network analysisR01MH121487 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, STEPHEN EDWARD PAUCHA · 2020 to 2021
$1.4MUC Santa Cruz Training Program In Genomic SciencesT32HG008345 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, GREEN, RICHARD EDWARD · 2015 to 2020
$1.4MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kA human neurodevelopmental model of Fetal Alcohol Spectrum DisordersK01AA026911 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TRUJILLO, CLEBER A · 2019 to 2020
$289kNHGRI NIH HHS R01 HG004659NHGRI NIH HHS T32 HG008345NHGRI NIH HHS U24 HG009889NHGRI NIH HHS U41 HG009889NHLBI NIH HHS R01 HL137223NIAAA NIH HHS K01 AA026911NIGMS NIH HHS K12 GM068524NIH HHS S10 OD026929NIMH NIH HHS R01 MH113545NIMH NIH HHS R01 MH121487NIMH NIH HHS U19 MH107367
Abstract
The evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 (
Indexed as
AllelesAlternative SplicingAmino Acid SubstitutionAnimalsBinding SitesBiological EvolutionCell ProliferationCerebral CortexCRISPR-Cas SystemsGene Expression Regulation, DevelopmentalGenetic VariationGenomeGenome, HumanHaplotypesHominidaeHumansNerve Tissue ProteinsNeuro-Oncological Ventral AntigenNOVA1 protein, humanRNA-Binding Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.