Evidence map›Paper›PMID 33574137›Full record

ArticleJournal of neurointerventional surgery2021

A novel rabbit thromboembolic occlusion model.

Yong-Hong Ding, Seán Fitzgerald, Yang Liu, Daying Dai, Daniel Jakaitis, Karen Doyle, Waleed Brinjikji, David F Kallmes, Luis Savastano, Ramanathan Kadirvel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurointerventional surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Measuring artery diameter in rabbit angiograms for neurovascular disease modeling applications and device testing.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  4. Article
  5. A Thrombectomy Model Based on Ex Vivo Whole Human Brains.AJNR. American journal of neuroradiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yong-Hong Ding *Radiology, Mayo Clinic, Rochester, Minnesota, USA ding.yonghong@mayo.edu.
Seán Fitzgerald *CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0001-6634-092X
Yang Liu *Radiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-9132-0258
Daying DaiRadiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0003-4051-6450
Daniel JakaitisRadiology, Mayo Clinic, Rochester, Minnesota, USA.
Karen DoylePhysiology, CURAM, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0001-8984-6296
Waleed BrinjikjiRadiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0001-5271-5524
David F KallmesRadiology, Mayo Clinic, Rochester, Minnesota, USA.
Luis SavastanoNeurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
Ramanathan KadirvelRadiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-6786-9953
Mayo Clinic · USOllscoil na Gaillimhe – University of Galway · IE

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
Impact of Clot Histological and Physical Properties on Revascularization Strategies in Acute Ischaemic Stroke - Administrative SupplementR01NS105853 · NINDS · MAYO CLINIC ROCHESTER · PI BRINJIKJI, WALEED · 2018 to 2022
$2.0M
NINDS NIH HHS R01 NS076491NINDS NIH HHS R01 NS105853
6 · The paper itself

Abstract

backgroundTo develop a preclinical thromboembolic occlusion model for studying revascularization strategies.

methodsClot analog with barium sulfate was injected into the distal aorta in 9 New Zealand white rabbits. The situation of aorta occlusion was compared among fibrin-rich (n=4), red blood cell (RBC)-rich (n=3), and whole blood clot analogs (n=2) using digital subtraction angiography. Arterial geometries, histologic features and circumferential stretch of the distal aorta in rabbits were compared with the common carotid artery in swine and the distal internal carotid artery (ICA) in humans. Aspiration thrombectomy and mechanical thrombectomy using a stent retriever were performed in two rabbits.

resultsThe aortic bifurcation was occluded after a single delivery of clot in 4 cases. It was occluded after the second clot injection in the 5 remaining rabbits. Fragmentation of RBC-rich clots occurred during clot injection in 2 cases. The mean diameters of the distal aorta and right common iliac artery in rabbits were 3.7±0.4 and 2.8±0.3 mm, respectively; the mean diameters of human ICA, and first and second segments of the middle cerebral artery (M1, M2) were 3.6±0.4, 3.1±0.4, and 2.4±0.4 mm, respectively. Arterial revascularization was achieved in both rabbits. Geometric, mechanical and histological factors of the distal aorta in rabbit were more close to human distal ICA than swine carotid artery.

conclusionArterial occlusion can be achieved at the aortic bifurcation in rabbits, which is comparable to human ICA bifurcation. This thrombectomy model has the potential to be used for testing of thrombectomy devices.

Indexed as

Arterial Occlusive DiseasesRabbitsStrokeAnimalsInfarction, Middle Cerebral ArteryMiddle Cerebral ArteryStentsThrombectomyTreatment Outcomestrokethrombectomy

Identifiers

PMID33574137
PMCPMC8355249
OpenAlexW3129020815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.