Evidence map›Paper›PMID 33574088›Full record

ArticleCancer research2021

Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3.

Evelina Mocci, Prosenjit Kundu, William Wheeler, Alan A Arslan, Laura E Beane-Freeman, Paige M Bracci, Paul Brennan, Federico Canzian, Mengmeng Du, Steven Gallinger and 67 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

77 authors at 20 institutions in 12 countries.

Evelina Mocci *Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Prosenjit Kundu *Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
William WheelerInformation Management Services, Inc., Silver Spring, Maryland.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, New York.ORCID 0000-0002-7775-8085
Laura E Beane-FreemanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-0518-8714
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4261-4583
Mengmeng DuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Loic Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Rachel E NealeDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Kala VisvanathanDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-0582-8005
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
William R BamletDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2903-1284
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Amanda L BlackfordDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-6519-4833
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Daniele CampaDepartment of Biology, University of Pisa, Pisa, Italy.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Erica J ChildsDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain.ORCID 0000-0001-5256-0163
Charles S FuchsYale Cancer Center, New Haven, Connecticut.
J Michael GazianoDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Edward L GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Michael G GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Manal M HassanDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Robert N HooverDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4486-7496
Robert C KurtzGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, New York.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre, Madrid, Spain.ORCID 0000-0003-2538-3784
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Kimmie NgDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Ann L ObergDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2539-9807
Salvatore PanicoDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Ulrike PetersCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Miquel PortaCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Kari G RabeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0002-7313-1875
Elio RiboliDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-9698-9954
Debra T SilvermanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Victoria L StevensBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.ORCID 0000-0003-0259-4407
Oliver StrobelDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0001-5100-8449
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, Texas.
Anne TjonnelandDepartment of Public Health, University of Copenhagen and Danish Cancer Society Research Center Diet, Genes and Environment, Copenhagen, Denmark.ORCID 0000-0003-4385-2097
Antonia TrichopoulouHellenic Health Foundation, World Health Organization Collaborating Center of Nutrition, Medical School, University of Athens, Greece.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, California.ORCID 0000-0002-5599-8387
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, New York.ORCID 0000-0003-3096-9595
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0003-3950-4815
Fangcheng YuanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0002-8443-6754
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York.
Laufey T AmundadottirDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0003-1859-8971
Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-7542-0662
Eric J JacobsDepartment of Public Health, University of Copenhagen and Danish Cancer Society Research Center Diet, Genes and Environment, Copenhagen, Denmark.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Nilanjan Chatterjee *Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Alison P Klein *Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland. rs221z@nih.gov aklein1@jhmi.edu.ORCID 0000-0003-2737-8399
Rachael Stolzenberg-Solomon *Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland. rs221z@nih.gov aklein1@jhmi.edu.ORCID 0000-0003-3698-7006
Center for Cancer Research · USJohns Hopkins University · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USMayo Clinic · USCancer Center of Hawaii · USDana-Farber Cancer Institute · USCentre international de recherche sur le cancer · FRDanish Cancer Society · DKLunenfeld-Tanenbaum Research Institute · CAMemorial Sloan Kettering Cancer Center · USNew York University · USThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USVanderbilt University · USAmerican Cancer Society · USChristus Santa Rosa Health System · USFederico II University Hospital · ITGerman Cancer Research Center · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, ELIZABETH D · 1993 to 2022
$54.6M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010193NCCDPHP CDC HHS U58 DP003862NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016087NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA097075NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA098870NCI NIH HHS R01 CA102765NCI NIH HHS R01 CA109767NCI NIH HHS R01 CA154823NCI NIH HHS R03 CA123546NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA182913NCI NIH HHS U01 CA182934NCI NIH HHS U01 CA247283NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182883NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHGRI NIH HHS R01 HG010480NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIEHS NIH HHS P30 ES000260World Health Organization 001
6 · The paper itself

Abstract

Germline variation and smoking are independently associated with pancreatic ductal adenocarcinoma (PDAC). We conducted genome-wide smoking interaction analysis of PDAC using genotype data from four previous genome-wide association studies in individuals of European ancestry (7,937 cases and 11,774 controls). Examination of expression quantitative trait loci data from the Genotype-Tissue Expression Project followed by colocalization analysis was conducted to determine whether there was support for common SNP(s) underlying the observed associations. Statistical tests were two sided and

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociCarcinoma, Pancreatic DuctalChromosomes, Human, Pair 2Cyclin TGenome-Wide Association StudyGenotypeHumansMembrane ProteinsPancreatic NeoplasmsRisk FactorsSmokingCCNT2 protein, humanCyclin TMembrane ProteinsTMEM163 protein, human

Identifiers

PMID33574088
PMCPMC8178175
OpenAlexW3127162284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.