Evidence map›Paper›PMID 33573678›Full record

ArticleNutrition & metabolism2021

Association of serum calcium levels with renal impairment and all-cause death in Chinese patients with newly diagnosed multiple myeloma: a cross-sectional, longitudinal study.

Jun Cheng, Wen Zhang, Yi Zhao, Xiayu Li, Rong Lv, Heng Li, Jianghua Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jun Cheng *Kidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China.
Wen Zhang *Department of Nephrology, The Yuhang District First People's Hospital, Hangzhou, China.
Yi ZhaoHematology Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China.
Xiayu LiKidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China.
Rong LvKidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China.
Heng LiKidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China.
Jianghua ChenKidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, 310003, China. chenjianghua@zju.edu.cn.ORCID http://orcid.org/0000-0002-3282-3998
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNFirst People's Hospital of Yuhang District · CN

Funding

Zhejiang Medical and Health Science and Technology Project 2016KYA087Zhejiang Natural Science Foundation LY19H050007
6 · The paper itself

Abstract

backgroundMore studies have shown that serum calcium has a crucial role in many types of cancers. However, few studies have determined the association between serum calcium levels and renal impairment (RI) and all-cause death in Chinese patients with multiple myeloma (MM).

methodsA total of 246 of 565 participants who were followed for > 6 months from a MM cohort at our institution were eligible for the retrospective study. A generalized additive model and smooth curve fitting were performed to investigate the cross-sectional relationship between the serum calcium level and RI at baseline. Multivariate-adjusted Cox regression models were fitted to assess the associations between baseline serum calcium levels and the onset of end-stage renal disease (ESRD) or death in patients with MM.

resultsA total of 172 of 565 patients (30.4%) with newly diagnosed MM presented with RI. The mean duration of follow-up was 26.64 months. Twenty-one patients (8.54%) died and 28 patients (11.52%) had ESRD. In patients with a serum calcium level > 2.30 mmol/L, the serum calcium level was independently associated with the occurrence of MM-related RI. Cox regression analysis showed that baseline serum calcium levels were consistently associated with a higher risk of all-cause death in the fully adjusted model, but were not associated with the occurrence of ESRD. When patients were categorized into two groups according to baseline mean serum calcium level, deaths occurred in 13 patients (15.1%) with a mean serum calcium level > 2.44 mmol/L compared to eight patients (5.0%) with a mean serum calcium level < 2.44 mmol/L (p < 0.05); Eighteen patients (11.46%) with a mean serum calcium level < 2.44 mmol/L progressed to ESRD compared to 13 patients (11.6%) with a serum calcium level > 2.44 mmol/L (p > 0.05).

conclusionsThis observational study showed that there was a nonlinear relationship between the serum calcium level and the presence of RI in patients with MM. An elevated baseline calcium level predicted all-cause death, but did not predict the occurrence of ESRD in patients with MM followed for > 6 months.

Indexed as

End-stage renal diseaseMortalityMultiple myelomaRenal impairmentSerum calcium level

Identifiers

PMID33573678
PMCPMC7879693
OpenAlexW3127793587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.