Evidence map›Paper›PMID 33573674›Full record

ArticleTrials2021

M.I.C.E-Mental Health Intervention for Children with Epilepsy: a randomised controlled, multi-centre clinical trial evaluating the clinical and cost-effectiveness of MATCH-ADTC in addition to usual care compared to usual care alone for children and young people with common mental health disorders and epilepsy-study protocol.

Sophie D Bennett, J Helen Cross, Anna E Coughtrey, Isobel Heyman, Tamsin Ford, Bruce Chorpita, Rona Moss-Morris, Sarah Byford, Emma Dalrymple, Colin Reilly and 9 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Sudden gains in modular CBT for mental health disorders in children and young people with epilepsy.Journal of child psychology and psychiatry, and allied disciplines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Sophie D BennettUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.ORCID http://orcid.org/0000-0002-1076-7112
J Helen CrossGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Anna E CoughtreyUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Isobel HeymanUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Tamsin FordDepartment of Psychiatry, Cambridge University, Cambridge, UK.
Bruce ChorpitaUCLA , California, Los Angeles, USA.
Rona Moss-MorrisInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Sarah ByfordInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Emma DalrympleUCL Great Ormond Street Institute of Child Health, London, UK.
Colin ReillyNational Centre for Young People with Epilepsy, Surrey, UK.
Terence StephensonUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Caroline DoréComprehensive Clinical Trials Unit, University College London, London, UK.
Sophia VaradkarGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
James BlackstoneComprehensive Clinical Trials Unit, University College London, London, UK.
Kashfia ChowdhuryComprehensive Clinical Trials Unit, University College London, London, UK.
Poushali GanguliInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Liz DeaneComprehensive Clinical Trials Unit, University College London, London, UK.
MICE Study Team
Roz ShafranUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. r.shafran@ucl.ac.uk.
Great Ormond Street Hospital · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBKing's College London · GBUniversity of Cambridge · GBUniversity College London · GB

Funding

Medical Research Council G108/625Programme Grants for Applied Research RP-PG-0616-20007
6 · The paper itself

Abstract

backgroundMental health disorders in the context of long-term conditions in children and young people are currently overlooked and undertreated. Evidence-based psychological treatments for common childhood mental health disorders (anxiety, depression and disruptive behaviour disorders) have not been systematically evaluated in young people with epilepsy despite their high prevalence in this population. The aim of this multi-site randomised controlled trial is to determine the clinical and cost-effectiveness of adding a modular psychological intervention to usual care for the mental health disorders in comparison to assessment-enhanced usual care alone.

methodsIn total, 334 participants aged 3-18 years attending epilepsy services will be screened for mental health disorders with the Strengths and Difficulties Questionnaire (SDQ) and the diagnostic Development and Wellbeing Assessment (DAWBA). Those identified as having a mental health disorder and consenting to the trial will be randomised to either receive up to 22 sessions of the modular psychological intervention (MATCH-ADTC) delivered over the telephone over 6 months by non-mental health professionals in addition to usual care or to assessment-enhanced usual care alone. Outcomes will be measured at baseline, 6 months and 12 months post-randomisation. It is hypothesised that MATCH-ADTC plus usual care will be superior to assessment-enhanced usual care in improving emotional and behavioural symptoms. The primary outcome is the SDQ reported by parents at 6 months. Secondary outcomes include parent-reported mental health measures such as the Revised Children's Anxiety and Depression Scale, quality of life measures such as the Paediatric Quality of Life Inventory and physical health measures such as the Hague Seizure Severity Scale. Outcome assessors will be blinded to group assignment. Qualitative process evaluations and a health economic evaluation will also be completed. DISCUSSION: This trial aims to determine whether a systematic and integrated approach to the identification and treatment of mental health disorders in children and young people with epilepsy is clinically and cost-effective. The findings will contribute to policies and practice with regard to addressing mental health needs in children and young people with other long-term conditions.

trial registrationISRCTN ISRCTN57823197 . Registered on 25 February 2019.

Indexed as

EpilepsyMental HealthAdolescentAnxietyChildCost-Benefit AnalysisHumansMulticenter Studies as TopicQuality of LifeRandomized Controlled Trials as TopicAnxietyCognitive behaviour therapyDepressionDisruptive behaviourEpilepsyMental healthNeurologyPaediatricTeletherapy

Identifiers

PMID33573674
PMCPMC7876975
OpenAlexW3126623542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.