ArticleCardiovascular diabetology2021
Gender differences in screening for glucose perturbations, cardiovascular risk factor management and prognosis in patients with dysglycaemia and coronary artery disease: results from the ESC-EORP EUROASPIRE surveys.
Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Hemoglobin A1c association patterns with cardiovascular outcomes among patients with diabetes mellitus following percutaneous coronary intervention: A systematic review.Diabetes & vascular disease researchPooled it
- Cardiovascular risk factors, exercise capacity and health literacy in patients with chronic ischaemic heart disease and type 2 diabetes mellitus in Germany: Baseline characteristics of the Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes study.Diabetes & vascular disease researchTrial
- Temporal and Regional Trends in Cardiovascular Mortality Associated With Diabetes Mellitus: A Nationwide Analysis From 1999 to 2020 in the United States.Health science reports · 2026Article
- [Sex and gender-specific aspects in prediabetes and diabetes mellitus - Clinical recommendations (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Sex-specific angiographic findings and clinical features in patients with myocardial infarction.Scientific reports · 2025Article
- Article
- The differences of metabolic profiles, socioeconomic status and diabetic retinopathy in U.S. working-age and elderly adults with diabetes: results from NHANES 1999-2018.Acta diabetologica · 2025Article
- Inverse association between pre-high-altitude potassium levels and coronary microvascular disease at high altitude: a case-control study.Frontiers in pharmacology · 2025Article
- The Gender Gap in the Relationship between Metabolic Syndrome and Restrictive Ventilatory Defects.Nutrients · 2024Article
- ProtecT-2-D trial protocol: cardiovascular protection in patients with type 2 diabetes and established heart and/or vascular disease at a cardio-metabolic clinic-a randomized controlled trial.Cardiovascular diabetology · 2024Article
- Homocysteine concentration in coronary artery disease and severity of coronary lesions.Journal of cellular and molecular medicine · 2024Article
- Trends in diabetes prevalence, awareness, treatment, and control in French-speaking Switzerland.Scientific reports · 2024Article
- Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states.Cardiovascular diabetology · 2024Article
- Sex-related differences for uric acid in the prediction of cardiovascular events in essential hypertension. A population prospective study.Cardiovascular diabetology · 2023Article
- Association of inflammatory markers with all-cause mortality and cardiovascular mortality in postmenopausal women with osteoporosis or osteopenia.BMC women's health · 2023Article
- Sex differences in type 2 diabetes.Diabetologia · 2023Review
- Gender-associated cardiometabolic risk profiles and health behaviors in patients with type 2 diabetes: a cross-sectional analysis of the Joint Asia Diabetes Evaluation (JADE) program.The Lancet regional health. Western Pacific · 2023Article
- [Sex and gender-specific aspects in prediabetes and diabetes mellitus-clinical recommendations (Update 2023)].Wiener klinische Wochenschrift · 2023Article
- Gender disparities in time-to-initiation of cardioprotective glucose-lowering drugs in patients with type 2 diabetes and cardiovascular disease: a Danish nationwide cohort study.Cardiovascular diabetology · 2022Article
- Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study.Cardiovascular diabetology · 2022Article
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Authors and funding
12 authors at 5 institutions in 6 countries.
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Abstract
backgroundGender disparities in the management of dysglycaemia, defined as either impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), in coronary artery disease (CAD) patients are a medical challenge. Recent data from two nationwide cohorts of patients suggested no gender difference as regards the risk for diabetes-related CV complications but indicated the presence of a gender disparity in risk factor management. The aim of this study was to investigate gender differences in screening for dysglycaemia, cardiovascular risk factor management and prognosis in dysglycemic CAD patients.
methodsThe study population (n = 16,259; 4077 women) included 7998 patients from the ESC-EORP EUROASPIRE IV (EAIV: 2012-2013, 79 centres in 24 countries) and 8261 patients from the ESC-EORP EUROASPIRE V (EAV: 2016-2017, 131 centres in 27 countries) cross-sectional surveys. In each centre, patients were investigated with standardised methods by centrally trained staff and those without known diabetes were offered an oral glucose tolerance test (OGTT). The first of CV death or hospitalisation for non-fatal myocardial infarction, stroke, heart failure or revascularization served as endpoint. Median follow-up time was 1.7 years. The association between gender and time to the occurrence of the endpoint was evaluated using Cox survival modelling, adjusting for age.
resultsKnown diabetes was more common among women (32.9%) than men (28.4%, p < 0.0001). OGTT (n = 8655) disclosed IGT in 17.2% of women vs. 15.1% of men (p = 0.004) and diabetes in 13.4% of women vs. 14.6% of men (p = 0.078). In both known diabetes and newly detected dysglycaemia groups, women were older, with higher proportions of hypertension, dyslipidaemia and obesity. HbA1c was higher in women with known diabetes. Recommended targets of physical activity, blood pressure and cholesterol were achieved by significantly lower proportions of women than men. Women with known diabetes had higher risk for the endpoint than men (age-adjusted HR 1.22; 95% CI 1.04-1.43).
conclusionsGuideline-recommended risk factor control is poorer in dysglycemic women than men. This may contribute to the worse prognosis in CAD women with known diabetes.
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