Evidence map›Paper›PMID 33573530›Full record

SynthesisPathogens and global health2021

Use of hydroxychloroquine and chloroquine in patients with COVID-19: a meta-analysis of randomized clinical trials.

Paulo Roberto Bignardi, Carolina Santos Vengrus, Bruno Matos Aquino, Alcindo Cerci Neto

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Pathogens and global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Potency of Xanthone Derivatives fromMolecules (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Review
  8. Innovations and development of Covid-19 vaccines: A patent review.Journal of infection and public health · 2022
    Review
  9. Article
  10. Article
  11. COVID-19 treatment in children: A systematic review and meta-analysis.Journal of family medicine and primary care · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paulo Roberto BignardiSchool of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil.ORCID 0000-0002-4730-0946
Carolina Santos VengrusSchool of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil.
Bruno Matos AquinoSchool of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil.
Alcindo Cerci NetoSchool of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil.ORCID 0000-0002-1702-7475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 has quickly become a public health problem worldwide, and treatment for this new disease is needed. Hydroxychloroquine is an antimalarial that

Indexed as

COVID-19 Drug TreatmentAdultAgedAged, 80 and overAntiviral AgentsChloroquineCOVID-19FemaleHumansHydroxychloroquineMaleMiddle AgedRandomized Controlled Trials as TopicSARS-CoV-2Treatment OutcomeAntiviral AgentsChloroquineHydroxychloroquineChloroquinecoronavirushydroxychloroquinemeta-analysisSARS-CoV-2

Identifiers

PMID33573530
PMCPMC7885725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.