Evidence map›Paper›PMID 33573356›Full record

ArticleInternational journal of molecular sciences2021

Design and Synthesis of N-Substituted 3,4-Pyrroledicarboximides as Potential Anti-Inflammatory Agents.

Aleksandra Redzicka, Żaneta Czyżnikowska, Benita Wiatrak, Katarzyna Gębczak, Andrzej Kochel

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Anti-Inflammatory Activity of Cyclic Imide Derivatives.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aleksandra RedzickaDepartment of Chemistry of Drugs, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.ORCID 0000-0003-1508-8327
Żaneta CzyżnikowskaDepartment of Inorganic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.ORCID 0000-0002-5758-9667
Benita WiatrakDepartment of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.ORCID 0000-0002-1404-2274
Katarzyna GębczakDepartment of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
Andrzej KochelDepartment of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 54-234 Wrocław, Poland.

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

In the present paper, we describe the biological activity of the newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides

Indexed as

Cell LineCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase InhibitorsDrug DesignEnzyme AssaysHumansImidesMagnetic Resonance SpectroscopyMolecular Docking SimulationMolecular StructurePyrrolesStructure-Activity RelationshipCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase InhibitorsImidesPTGS1 protein, humanPTGS2 protein, humanPyrrolesanalgesic activityCOX-1/COX-2 inhibitioncyclic imidesdocking studyinflammatory agentsMannich basespyrrolo[3,4-c]pyrrole

Identifiers

PMID33573356
PMCPMC7866801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.