Evidence map›Paper›PMID 33573322›Full record

ArticleCells2021

Aging and Microglial Response following Systemic Stimulation with

Inge C M Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Mercedes Valls Seron, Judith H M P Houben-Weerts, David J van Westerloo, Tom van der Poll, Willem A van Gool, Diederik van de Beek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Inge C M HooglandDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Dunja WesthoffDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Joo-Yeon Engelen-LeeDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Mercedes Valls SeronDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Judith H M P Houben-WeertsDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
David J van WesterlooIntensive Care Medicine, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Tom van der PollCentre for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam UMC, Amsterdam Infection and Immunity Institute, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands.
Willem A van GoolDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-3174-8233
Diederik van de BeekDepartment of Neurology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-4571-044X
Amsterdam UMC Location University of Amsterdam · NLAmsterdam University Medical Centers · NLLeiden University · NL

Funding

European Research Council ERC Starting Grant# 281156ZonMw TOP grant# 40-00812-98-10017 and Vidi grant# 016.116.358
6 · The paper itself

Abstract

Systemic infection is an important risk factor for the development cognitive impairment and neurodegeneration in older people. Animal experiments show that systemic challenges with live bacteria cause a neuro-inflammatory response, but the effect of age on this response in these models is unknown. Young (2 months) and middle-aged mice (13-14 months) were intraperitoneally challenged with live

Indexed as

AgingAnimalsDisease Models, AnimalEscherichia coliHumansMaleMiceMicrogliaageingEscherichia colimicrogliamicroglial activationmouse modelneuro-inflammationsystemic infection

Identifiers

PMID33573322
PMCPMC7912649
OpenAlexW3128206935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.