Evidence map›Paper›PMID 33573275›Full record

ArticleCancers2021

Research Strategies for Low-Survival Cancers.

Caroline Conway, Denis M Collins, Amanda McCann, Kellie Dean

Abstract readConference Proceedings
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caroline ConwayGenomics Core Facility, Biomedical Sciences Research Institute, Ulster University, Coleraine BT52 1SA, UK.ORCID 0000-0001-7470-8114
Denis M CollinsNational Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.ORCID 0000-0003-1043-6169
Amanda McCannUCD Conway Institute of Biomolecular and Biomedical Research and UCD School of Medicine College of Health and Agricultural Science (CHAS), University College Dublin, Belfield, Dublin 4, Ireland.ORCID 0000-0003-1911-3307
Kellie DeanSchool of Biochemistry and Cell Biology, 3.91 Western Gateway Building, University College Cork, Cork T12 XF62, Ireland.ORCID 0000-0002-3213-8181

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While substantial progress has been made to improve the diagnosis, prognosis, and survivorship of patients with cancer, certain cancer types, along with metastatic and refractory disease, remain clinical challenges. To improve patient outcomes, ultimately, the cancer research community must meet and overcome these challenges, leading to improved approaches to treat the most difficult cancers. Here, we discuss research progress aimed at gaining a better understanding of the molecular and cellular changes in tumor cells and the surrounding stroma, presented at the 56th Irish Association for Cancer Research (IACR) Annual Conference. With a focus on poor prognosis cancers, such as esophageal and chemo-resistant colorectal cancers, we highlight how detailed molecular knowledge of tumor and stromal biology can provide windows of opportunity for biomarker discovery and therapeutic targets. Even with previously characterized targets, such as phosphoinositide 3-kinase (PI3K), one of the most altered proteins in all human cancers, new insights into how this protein may be more effectively inhibited through novel combination therapies is presented.

Indexed as

chromatin re-modellingimmuno-oncologyinsulin signalinglow survival cancertransforming growth factor-beta signaling

Identifiers

PMID33573275
PMCPMC7866553

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.