Evidence map›Paper›PMID 33573232›Full record

ArticlePharmaceutics2021

Preclinical Evaluation of

Ayman Abouzayed, Sara S Rinne, Hamideh Sabahnoo, Jens Sörensen, Vladimir Chernov, Vladimir Tolmachev, Anna Orlova

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Influence of Peptide-Based Chelator Sequences on HER2-Targeting Radiopeptide.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Preclinical Evaluation of a Novel High-Affinity Radioligand [International journal of molecular sciences · 2023
    Article
  9. The GRPR Antagonist [Diagnostics (Basel, Switzerland) · 2023
    Article
  10. Phase I Trial of [Cancers · 2023
    Article
  11. Frontiers in oncology · 2023
    Article
  12. Optimization of the Pharmacokinetic Profile of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ayman AbouzayedDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Sara S RinneDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Hamideh SabahnooDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Jens SörensenDivision of Radiology and Nuclear Medicine, Department of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
Vladimir ChernovDepartment of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of Sciences, Tomsk 634009, Russia.
Vladimir TolmachevResearch Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-6122-1734
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0001-6120-2683
Uppsala University · SERussian Academy of Sciences · RU

Funding

Cancerfonden 20 0814 UsFCancerfonden 20 0815 PjFCancerfonden 2017/425Vetenskapsrådet 2019-00986
6 · The paper itself

Abstract

backgroundGastrin-releasing peptide receptor (GRPR) is an important target for imaging of prostate cancer. The wide availability of single-photon emission computed tomography/computed tomography (SPECT/CT) and the generator-produced

methodsSynthetically produced mercaptoacetyl-Ser-Ser-Ser (maSSS)-PEG

resultsPeptides were radiolabeled with high yields (>98%), demonstrating GRPR specific binding and slow internalization in PC-3 cells. [

conclusionThe GRPR antagonist maSSS-PEG

Indexed as

gastrin-releasing peptide receptor antagonistprostate cancerRM26single-photon emission computed tomographytechnetium-99m

Identifiers

PMID33573232
PMCPMC7912279
OpenAlexW3127091815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.