Evidence map›Paper›PMID 33573148›Full record

ArticleMicroorganisms2021

Susceptibility Testing Is Key for the Success of Cefiderocol Treatment: A Retrospective Cohort Study.

Alexandre Bleibtreu, Laurent Dortet, Remy A Bonnin, Benjamin Wyplosz, Sophie-Caroline Sacleux, Liliana Mihaila, Hervé Dupont, Helga Junot, Vincent Bunel, Nathalie Grall and 5 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Real-world experience with cefiderocol therapy forAntimicrobial stewardship & healthcare epidemiology : ASHE · 2023
    Article
  10. Mediterranean journal of hematology and infectious diseases · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. New Drugs for the Treatment ofAntibiotics (Basel, Switzerland) · 2022
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Alexandre BleibtreuInfectious Disease Unit, La Pitié-Salpétrière University Hospital, AP-HP, University of Paris, 75013 Paris, France.ORCID 0000-0001-5145-4174
Laurent DortetMicrobiology Laboratory, Bicêtre University Hospital, AP-HP Paris Saclay University, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0001-6596-7384
Remy A BonninMicrobiology Laboratory, Bicêtre University Hospital, AP-HP Paris Saclay University, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0002-2307-3232
Benjamin WyploszInfectious Disease Unit, Bicêtre University Hospital, AP-HP Paris Saclay University, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0002-9779-9044
Sophie-Caroline SacleuxIntensive Care Unit, Paul Brousse Hospital, AP-HP Paris Saclay University, 94800 Villejuif, France.
Liliana MihailaMicrobiology Laboratory, Bicêtre University Hospital, AP-HP Paris Saclay University, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0003-0273-2961
Hervé DupontIntensive Care Unit, Amiens University Hospital, 80054 Amiens, France.
Helga JunotPharmacy Department, La Pitié-Salpétrière University Hospital, AP-HP, University of Paris, 75013 Paris, France.ORCID 0000-0001-6965-4553
Vincent BunelPneumology Department, Bichât University Hospital, AP-HP, University of Paris, 75018 Paris, France.ORCID 0000-0002-5080-6331
Nathalie GrallIAME, INSERM, University of Paris, 75870 Paris, France.
Keyvan RazaziIntensive Care Unit, Henri Mondor University Hospital, AP-HP, 94010 Créteil, France.
Clara DuranInfectious Disease Unit, Raymond-Poincaré University Hospital, AP-HP Paris Saclay University, 92380 Garches France.ORCID 0000-0002-1509-2660
Pierre TattevinInfectious Disease and Intensive Care Unit, Pontchaillou University Hospital, 35000 Rennes, France.
Aurélien DinhInfectious Disease Unit, Raymond-Poincaré University Hospital, AP-HP Paris Saclay University, 92380 Garches France.
On Behalf Of The Cefiderocol French Study Group
Université Paris-Saclay · FRUniversité Paris Cité · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Universitaire Amiens-Picardie · FRHôpital Pontchaillou · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cefiderocol is a novel siderophore cephalosporin, which has proven in vitro activity against carbapenem-resistant (CR) Gram-negative pathogens and stability towards all carbapenemases. The aim of this study was to describe the first cases of prescriptions and the efficacy of cefiderocol for compassionate use in the 2 months following its access in France. We performed a national retrospective study of all patients who received at least one dose of cefiderocol from 2 November 2018 to 5 November 2019. We collected clinical characteristics and outcome through a standard questionnaire. Bacterial isolates from 12 patients were centralized and analyzed in the French National Reference Center for Antimicrobial Resistance, and sequenced using Illumina technology. Finally, 13 patients from 7 French university hospitals were included in the study. The main type of infection treated by cefiderocol was respiratory tract infections (RTI,

Indexed as

bacterial resistancecarbapenemcefiderocolPseudomonas aeruginosarespiratory tract infection

Identifiers

PMID33573148
PMCPMC7911443
OpenAlexW3127842317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.