Evidence map›Paper›PMID 33573118›Full record

ArticleAntibiotics (Basel, Switzerland)2021

The P.E.A.N.U.T. Method: Update on an Integrative System Approach for the Treatment of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children.

Henrik Szőke, Márta Maródi, Jan Vagedes, Balázs Székely, István Magyarosi, Adél Bedő, Veronika Fellegi, Krisztina Somogyvári, Péter Móricz

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Henrik SzőkeDepartment of IM, Faculty of Health Sciences, University of Pécs, 7623 Pécs, Hungary.ORCID 0000-0002-7243-5789
Márta MaródiDepartment of Otolaryngology, Szt. Borbála Hospital, 2800 Tatabánya, Hungary.
Jan VagedesDepartment of Neonatology, University Children's Hospital Tubingen, 72016 Tubingen, Germany.ORCID 0000-0002-0021-088X
Balázs SzékelyCello Health Insight, Advanced Analytics Manager, London EC1M 7AP, UK.
István MagyarosiDepartment of Otolaryngology, Balassa János Hospital, 7100 Szekszárd, Hungary.ORCID 0000-0002-4587-3281
Adél BedőOutpatient Clinic, 8000 Székesfehérvár, Hungary.
Veronika FellegiOutpatient Clinic, 8000 Székesfehérvár, Hungary.
Krisztina SomogyváriDepartment of Otorhinolaryngology and Head-Neck Surgery, Clinical Center, University of Pécs, 7621 Pécs, Hungary.ORCID 0000-0002-6028-8048
Péter MóriczDepartment of Otolaryngology, Balassa János Hospital, 7100 Szekszárd, Hungary.ORCID 0000-0001-8815-0625
Kodolányi János University of Applied Sciences · HUSzent János Kórház · HUUniversity of Pecs · HUInsight Healthcare · GBSzent Borbála Kórház · HUUniversity Children's Hospital Tübingen · DE

Funding

Software AG - Stiftung P126666
6 · The paper itself

Abstract

BACKGROUND AND

objectivesBased on our previous single-center study on optimization of treatment of chronic otitis media with effusion (COME) and adenoid hypertrophy (AH) in children using a noninvasive system approach to lower the necessity of antibiotics, analgesic use, and surgical interventions, we proceeded to perform a multicenter investigation in an outpatient setting. The purpose of the previous prospective study in 2013-2015 was to compare outcomes in the treatment of COME and AH using the noninvasive multimodal integrative method (IM) versus conventional treatment practice (COM). MATERIALS AND

methodsIn this paper, we retrospectively analyze the data of patients treated with the integrative method between 2017 and 2020 in a multicenter setting and compared the outcomes with data from 2013-2015 in order to evaluate generalizability. In both periods, all eligible and willing participants were included and treated with the IM protocol under real-life conditions. The treatment involved pneumatization exercises, education, an antiallergic diet, nasal hygiene, useful constitutional therapy, and thermal interventions (P.E.A.N.U.T.). A total of 48 versus 28 patients, aged 1-8, were assessed, presenting with COME and AH, with moderate to severe hearing impairment at entry.

resultsThe significant improvement found in both audiometric measures (intact hearing) and tympanometric measures (normal A-type curve) was similar in both datasets with respect to conventional treatment. The new data confirms that the P.E.A.N.U.T. method results in a significant reduction of antibiotics, analgesic use, and surgical interventions.

conclusionIn this multicenter trial, we confirm the effectiveness of the noninvasive system approach for the treatment of COME in lowering the need for antibiotics and analgesic use and elective surgery. This could be especially important with respect to a generally observed increase in antibiotic resistance. The method is easy to perform in different clinical settings and is effective, safe, and well-tolerated.

Indexed as

adenoid hypertrophyanalgesicsantibioticschildrenchronic otitis media with effusionintegrative therapysurgical interventions

Identifiers

PMID33573118
PMCPMC7911258
OpenAlexW3126456308

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.