Evidence map›Paper›PMID 33572963›Full record

ArticlePharmaceutics2021

Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells.

Yoon-Jee Chae, Min-Soo Kim, Suk-Jae Chung, Mi-Kyung Lee, Kyeong-Ryoon Lee, Han-Joo Maeng

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Medications, epilepsy and climate change: Added layers of complexity.British journal of clinical pharmacology · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yoon-Jee ChaeCollege of Pharmacy, Woosuk University, Wanju-gun 55338, Korea.ORCID 0000-0003-4921-4192
Min-Soo KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.ORCID 0000-0001-9229-4701
Suk-Jae ChungCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Mi-Kyung LeeCollege of Pharmacy, Woosuk University, Wanju-gun 55338, Korea.
Kyeong-Ryoon LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.
Han-Joo MaengCollege of Pharmacy, Gachon University, Incheon 21936, Korea.
Seoul National University · KRWoosuk University · KRGachon University · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

Gachon University research fund of 2020 GCU-2020-02450001Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Programs KGM5212022
6 · The paper itself

Abstract

Calcitriol, a vitamin D

Indexed as

basic modelcalcitriolCYP inductionHepaRGhuman cryopreserved hepatocytesPBPK modelstatic mechanistic model

Identifiers

PMID33572963
PMCPMC7911399
OpenAlexW3129014725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.